Reaction with sodium sulfide

The analogous reaction with sodium sulfide gives a dimeric product 4 that contains a disulfide bridge.212... 

Tertiary nitro compounds are converted into the corresponding thiols by the reaction with sodium sulfide and sulfur (S8) in DMSO followed by the reduction with Al-Hg. (Eq. 7.12). Secondary and primary nitro compounds do not give thiols in these reactions instead, a complex set of product is formed.13... 

The subsequent reaction of the pure 1-nitroanthraquinone to 1-aminoan-thraquinone used to be carried out mainly by reaction with sodium sulfides in an alkaline medium and is now performed by nucleophilic replacement of the nitro group with ammonia in organic solvents, affording up to 98% yield. The overall reaction affords approximately 70% yield, in comparison to the roughly 50% yielded by the classical method which proceeds via the 1-sulfonic acid. Moreover, the newer method is also superior to the old one because recyclization of the solvent makes it ecologically more attractive. 

Yu and Bailey (1992) studied the reaction of nitrobenzene with four sulfide minerals under anaerobic conditions. Observed half-lives of nitrobenzene were 7.5, 40, 105, and 360 h for the reaction with sodium sulfide, alabandite (manganese sulfide), sphalerite (zinc sulfide), and molybdenite (molybdenum sulfide), respectively. Aniline and elemental sulfur were found as reduction products of nitrobenzene-manganese sulfide reaction. Aniline was also a reduction product in the nitrobenzene-molybdenum sulfide and nitrobenzene-sodium sulfide reactions. Several unidentified products formed in the reaction of nitrobenzene and sphalerite (Yu and Bailey, 1992). 

The salts (294) (Section VII, J, 1) are useful intermediates for the preparation of other meso-ionic systems by reaction with appropriate nucleophiles. Thus, reaction with sodium sulfide in dimethyl formamide yields the l,2,3,4-tetrazole-5-thiones (295), a new class of meso-ionic heterocycle. The 1,3-diphenyl derivative (295, R = = Ph) has a... 

On reaction with sodium sulfide in DMF, easily accessible racemic 2,2 -bis(bromomethyl)-l,l -binaphthyl 168 afforded dihydrothiepine 23 in 99% yield (Scheme 26) <1994JOC1326>. The racemic thiepine 23 was resolved by liquid chromatography on triacetylcellulose on a preparative scale to give (R)-(—)-23 (90% yield, 97% ee) and (. )-(+)-23 (83% yield, 100% ee) (Section 13.03.4.2). Alternatively, reaction of diamine ( 5)-(—)-198, which is derived from an enantiomer (.) )-(+)-197, and methyl iodide in MeCN and subsequent reaction with Na2S-9H20 in DMF gave ( S)-(+)-23 in 35% yield. 

Placing the chloride in contact with finely divided sodium caused an explosion after a short induction period [1]. Reaction with sodium sulfide gives molybdenum disulfide in a vigorous deflagration autoignition will occur on mixing if the sodium sulfide is... 

The two substituents on the /3-lactam can be longer and either saturated or unsaturated alkyl groups. The bromo alcohol 259 undergoes cyclization in the presence of base (triethylamine was found to give the best result) to yield the cyclic ether 260 <2005PAC2061>. The unsaturated diiodide 261 yields 262 upon reaction with sodium sulfide <1995TL7913>. 

Since these dithiocarbamates appeared to be suitable compounds for generating quinonemethide intermediates, we investigated their reaction with sodium sulfide. It was found that 3,5-di-ferf-butyl-4-hydroxybenzyl-2V,N-dimethyldithiocarbamate reacts with sodium sulfide to produce bis (3,5-di-teft-butyl-4-hydroxybenzyl) sulfide, XIII, in essentially quantitative yield (20). 

The latter product on reaction with sodium sulfide forms an unstable sodium salt... 

When 2-bromo-4,5-difluoronitrobenzene is heated with sodium sulfide, a diaryl sulfide is formed. The nitro group activates halogens in ortho-and para positions for nucleophilic displacements. Which of the activated halogens is replaced in the reaction with sodium sulfide giving a diaryl sulfide, and what is the product ... 

Although the triaminocyclopropenium ion is stable to water, even hot water, unlike the trichloro and triphenyl derivatives, this ion readily reacts with the hydroxide ion at room temperature to afford diamino-cyclopropenone (77) as the major product and an acrylamide derivative (75) as the minor product i ) (Eq. 10). On the other hand, the reaction with sodium sulfide yields diaminocyclopropenethione (79) and di-... 

In a study related to the conformational properties of the cyclohexane-fused six-membered heterocycles, new bicyclic dithiolanes, 285-/ra r (Scheme 52) and 285-crr (not shown), were prepared along the reaction pathway, as precursors used further for the syntheses of 2-methyl substituted and unsubstituted /ra r-fused 4a,5,6,7,8,8a-hexahydro-2//,4//-1,3-benzodithiines, exemplified by structure 288-/ra ir (R=R = H) <2002JOC1910>. Thus, ditosylation of cis-Z-hydroxymethyl cyclohexanol 284, and subsequent reaction with sodium sulfide and sulfur, provided a mixture of new bicyclic products 285 and 286, albeit in very low yields, with configurational inversion at C-1. These were reduced by LiAlH4 to provide /ra r-2-mercaptomethyl cyclohexanethiol 2 l-trans. Upon acetalization or transacetalization, the desired 2SS-trans derivative was obtained. The same methodology with the precursor 2E4-trans was extended to the preparation of the r-fused bicyclic compounds 285-288. 

A few halogenated 3-pyrazolin-5-thiones are known (Table XVIII). These are prepared from the methyl chlorides of 3- or 4,5-dichloro-pyrazole by reaction with sodium sulfide or potassium hydrogen sulfide.795,981 Michaelis988,992 has reported that 3-pyrazolin-5-selenones form dichlorides and di- and tetrabromides when treated with chlorine or bromine. No specific structures were suggested. 

Sulfides (thioethers) can be obtained by replacing the halogen of alkyl and suitable aryl halides in a reaction with sodium sulfide, this being analogous to the preparation of thiols and disulfides. The reaction is usually carried out... 

Since the residue in the stillpot from the steam distillation contains soluble mercury salts, place it in a special container for solutions of mercuric salts do not pour it down the drain. If directed to do so by your instructor, you may convert the soluble mercuric salts into insoluble mercuric sulfide by reaction with sodium sulfide or hydrosulfide collect the mercuric sulfide by vacuum filtration for recycling. Flush the other aqueous solutions down the drain with water. Pour the dichloromethane recovered as the forerun in the distillation into a container for halogenated organic solvents. Dilute the filtrate... 

Sulfur functionalities can be also introduced on the sucrose skeleton. Activation of both terminal hydrojgil groups in 22 as mesylates and further reaction with sodium sulfide affords di-mercaptane 35 (Scheme 8). 

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