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Reactions with Grignard reagents

In a side-chain containing a double-bond 3 to the oxirane, double-bond migration has also been observed. The effects of the solvent and the reagent have been examined in the reaction of vinyl-magnesium bromide and phenyloxirane. Acetylenic oxirane gives a complicated mixture of products with a Grignard reagent, but the Cu halide-catalyzed reaction leads to an allene alcohol (Eq. [Pg.99]

Although a regioselective reaction occurs with butadienylmagnesium chloride, the selectivity in the formation of the normal addition product is not total (Eq. 232).  [Pg.99]

Similar products have been reported by other authors. The very stereoselective synthesis of 1,5-dialkadienes takes place with a good yield. The newly formed double bond exhibits (E)-geometry (Eq. 233). °  [Pg.100]

Homoallyl alcohols have been obtained in the presence of a catalytic quantity of Cul (Eq. 234).  [Pg.100]

Other authors have also described copper catalysis in the Grignard reaction. In the presence of copper salt, cyclohexene oxide reacts with phenylmagnesium chloride under mild conditions to give tra s-2-phenylcyclohexanol in good yield in the absence of the catalyst, the conversion is low. At the same time, benzylmagnesium chloride led to a yield of 90% even without the catalyst. The reactions between epoxynitriles and Grignard reagents have likewise been studied in detail.  [Pg.100]


Section 20 20 Nitriles are useful starting materials for the preparation of ketones by reaction with Grignard reagents... [Pg.877]

Whereas sulfolane is relatively stable to about 220°C, above that temperature it starts to break down, presumably to sulfur dioxide and a polymeric material. Sulfolane, also stable in the presence of various chemical substances as shown in Table 2 (2), is relatively inert except toward sulfur and aluminum chloride. Despite this relative chemical inertness, sulfolane does undergo certain reactions, for example, halogenations, ting cleavage by alkah metals, ring additions catalyzed by alkah metals, reaction with Grignard reagents, and formation of weak chemical complexes. [Pg.68]

Osmium tetroxide, reaction with alkenes, 235-236 toxicity of, 235 Oxalic add, structure of, 753 Oxaloacetic acid, structure of, 753 Oxetane, reaction with Grignard reagents, 680 Oxidation, 233, 348 alcohols, 623-626 aldehydes, 700-701 aldoses, 992-994 alkenes, 233-236 biological, 625-626 phenols, 631 sulfides, 670 thiols, 668... [Pg.1310]

The work on vinyl sulphones and their reactions with Grignard reagents, in the presence of transition metal catalysts, all emanates from Julia s laboratory191-195, with the exception of a note196 that presents evidence for SET processes in the alkylation of vinyl sulphones by organometallic reagents. [Pg.957]

From Glycosyl Thiocyanates by Reaction with Grignard Reagents. 183... [Pg.179]


See other pages where Reactions with Grignard reagents is mentioned: [Pg.353]    [Pg.848]    [Pg.265]    [Pg.79]    [Pg.151]    [Pg.174]    [Pg.528]    [Pg.540]    [Pg.563]    [Pg.563]    [Pg.563]    [Pg.564]    [Pg.623]    [Pg.691]    [Pg.722]    [Pg.848]    [Pg.260]    [Pg.96]    [Pg.775]    [Pg.1282]    [Pg.1283]    [Pg.1283]    [Pg.1297]    [Pg.1297]    [Pg.1303]    [Pg.1308]    [Pg.21]    [Pg.732]    [Pg.88]    [Pg.647]    [Pg.543]    [Pg.868]   
See also in sourсe #XX -- [ Pg.526 , Pg.545 , Pg.546 , Pg.567 , Pg.574 , Pg.1030 , Pg.1205 , Pg.1215 , Pg.1216 , Pg.1217 ]

See also in sourсe #XX -- [ Pg.94 , Pg.146 ]

See also in sourсe #XX -- [ Pg.227 ]

See also in sourсe #XX -- [ Pg.94 , Pg.127 , Pg.146 ]




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1.2- Dithiol-3-ones reaction with Grignard reagents

1.2.4- Triazines reaction with Grignard reagents

2- Cyclohexenone reactions with Grignard reagents

7- -6,7-dihydro reaction with Grignard reagents

Acetylenic Grignard reagents, reactions with

Acid chloride, alcohols from reaction with Grignard reagents

Acid derivatives reaction with Grignard reagents

Adenosine, 8-bromocoupling reactions with Grignard reagents

Alcohols from Reaction of Carbonyl Compounds with Grignard Reagents

Aldehydes reaction with Grignard reagents

Aldehydes, reaction with allylic Grignard reagents

Alkenes reaction with Grignard reagents

Alkyl halides, reaction with indole Grignard reagents

Alkynes reaction with Grignard reagents

Allenyl halides, reactions with Grignard reagents

Allyl halides, reaction with Grignard reagents

Amide, sodium reaction with Grignard reagents

Amides reaction with Grignard reagents

Amines allylic, reaction with Grignard reagents

Amino ethers reaction with Grignard reagents

Arsinates reactions with Grignard reagents

Azlactones reaction with Grignard reagents

Basicity reaction with Grignard reagents

Benzophenone reaction with Grignard reagents

Benzophenones, reactions with Grignard reagents

Benzothiazole, 2-chlorocoupling reactions with Grignard reagents

Carbamates reaction with Grignard reagents

Carbamates, vinylogous reaction with Grignard reagents

Carbon dioxide reaction with Grignard reagents

Carbonyl compounds, reactions with organolithiums or Grignard reagents

Carboxylic acids by reaction of Grignard reagent with

Carboxylic acids ester reaction with Grignard reagents

Conjugated compounds, reaction with Grignard reagents

Cross-coupling reactions alkyl halides with Grignard reagents

Cyclobutanone reaction with Grignard reagent

Dimethyl sulfate, reaction with Grignard reagents

Diones, reactions with Grignard reagents

Epoxide reaction with Grignard reagents

Epoxides reaction with Grignard reagents

Epoxides vinylic, reaction with Grignard reagents

Esters reaction with Grignard reagents

Ethanol, 2-bromoacetate reaction with aryl Grignard reagents

Ethers allylic, reaction with Grignard reagents

Ethers propargylic, reaction with Grignard reagents

Ethers, a-halo reaction with aryl Grignard reagents

Ethyl benzoate reaction with Grignard reagents

Ethyl formate reaction with Grignard reagents

Ethylene oxide, reaction with Grignard reagents

Ethylene, 1,1-dichlorocoupling reactions with alkyl Grignard reagents

Ethylene, 1,2-dichlorocoupling reactions with vinylic Grignard reagents

Ethylene, l-bromo-2-phenylthiocoupling reaction with alkyl Grignard reagents

Ethylene, l-bromo-2-phenylthiocoupling reaction with secondary alkyl Grignard reagents

Formaldehyde reaction with Grignard reagents

Formamides reaction with Grignard reagents

Formic acid reaction with Grignard reagents

Grignard reagent cadmium halide reaction with

Grignard reagent metal compound reaction with

Grignard reagent metal halide reaction with

Grignard reagent reaction with carboxylic acids

Grignard reagent reaction with oxetanes

Grignard reagent zinc halide reaction with

Grignard reagents coupling reaction with bromobenzene

Grignard reagents coupling reactions with alkyl halides

Grignard reagents picolyl, reactions with

Grignard reagents pyridyl, reactions with

Grignard reagents pyrrole, reactions with electrophiles

Grignard reagents reaction mechanism, with

Grignard reagents reaction with a-alkoxy acyclic ketones

Grignard reagents reaction with acetals

Grignard reagents reaction with acetone

Grignard reagents reaction with acid

Grignard reagents reaction with acyl chlorides to form

Grignard reagents reaction with acyl halides

Grignard reagents reaction with alcohols

Grignard reagents reaction with allylic epoxides

Grignard reagents reaction with amides or nitriles to form

Grignard reagents reaction with anhydrides

Grignard reagents reaction with aryl oxazolines

Grignard reagents reaction with aziridines

Grignard reagents reaction with bromohydrins

Grignard reagents reaction with cadmium chloride

Grignard reagents reaction with carbonyl compounds

Grignard reagents reaction with diazonium salts

Grignard reagents reaction with dithioesters

Grignard reagents reaction with esters to form tertiary

Grignard reagents reaction with ethyl orthoformate

Grignard reagents reaction with imines

Grignard reagents reaction with iminium salts

Grignard reagents reaction with iodine

Grignard reagents reaction with isocyanates

Grignard reagents reaction with isothiocyanates

Grignard reagents reaction with ketals

Grignard reagents reaction with ketones

Grignard reagents reaction with oxiranes

Grignard reagents reactions

Grignard reagents reactions with electrophiles

Grignard reagents, alkyl reaction with cyclohexanone

Grignard reagents, benzyl, reaction with

Grignard reagents, benzyl, reaction with sulfoxides

Grignard reagents, reaction with acid chlorides

Grignard reagents, reaction with acyl chlorides

Grignard reagents, reaction with alkyl halides

Grignard reagents, reaction with enol-ketones

Grignard reagents, reaction with imides

Grignard reagents, reaction with lactams

Grignard reagents, reaction with lactones

Grignard reagents, reaction with sulfonium

Grignard reagents, reaction with sulfoxides

Grignard reagents, reaction with water

Grignard reagents, reactions with alkenyl halides

Grignard reagents, reactions with aryl halides

Grignard reagents, reactions with pyridines

Grignard reagents, reactions with pyrimidines

Grignard reagents, reactions with silanes

Isocyanides reactions with Grignard reagents

Isoquinoline, 2-chlorocoupling reactions with Grignard reagents

Ketones addition reaction with Grignard reagents

Ketones, reaction with allylic Grignard reagents

Ketones, reaction with indole Grignard reagents

Magnesium, reaction with alkyl halides form Grignard reagents

Mercury bromide, reaction with Grignard reagent

Methyl crotonate, reaction with »-butyl Grignard reagent and cuprous

Nitriles preparation reaction with Grignard reagents

Nitriles reaction with Grignard reagents

Organozinc compounds reaction with Grignard reagents

Ortho esters, reactions with Grignard reagents

Orthoesters reaction with Grignard reagents

Oxalic acid reactions with Grignard reagents

Oxetane reaction with Grignard reagents

Oxirane reactions with Grignard reagents

Oxygen reaction with Grignard reagents

Peroxides reaction with Grignard reagents

Phenylacetylene reaction with Grignard reagents

Phosphites reaction with Grignard reagents

Purine, 6-chlorocoupling reactions with primary alkyl Grignard reagents

Purine, 6-methylthiocoupling reactions with primary alkyl Grignard reagents

Pyridinium salts reaction with Grignard reagents

Pyridyl sulfoxides reaction with Grignard reagents

Quinoline, 3-bromocoupling reactions with Grignard reagents

Quinoline, 8-hydroxyesters reaction with Grignard reagents

Quinones reaction with Grignard reagents

Reaction of Grignard reagents with nitriles

Reaction of an Ester with a Grignard Reagent

Reaction of esters with Grignard reagents

Reaction with Grignard and organolithium reagents

Reaction with butenyl Grignard reagent

Reactions of Epoxides with Grignard and Organolithium Reagents

Rearrangements reaction with Grignard reagents

Reduction reactions with Grignard reagent

Silyl Grignard reagents reactions with

Sulfides, vinyl reaction with Grignard reagents

Sulfinyl chloride, reaction with Grignard reagents

Sulfonate esters reaction with Grignard reagents

Sulfonates reaction with Grignard reagents

Sulfones, vinyl reaction with Grignard reagents

Sulfonyl chlorides reactions with Grignard reagents

Sulfur reaction with Grignard reagents

The Kumada Reactions Nickel-Catalyzed Cross-Coupling with Grignard Reagents

Thebaine reaction with Grignard reagents

Thiophene 3- bromo-, reaction with Grignard reagents

Triethyl orthoformate, reaction with Grignard reagents

Trimethyl borate, reaction with Grignard reagents

Vinyl ethers, reaction with Grignard reagents

With Grignard Reagents

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