Grignard reagents acyl chloride reactions with

Alternatively to Grignard reagents, diorganozinc compounds can also be introduced in iron-catalyzed coupling reactions with acyl chlorides to provide a wide range of polyfunctional ketones under mild reaction conditions. ... 

CO, BuaSnH, and NCCMe2N=NCMe2CN (AIBN). Aryl ketones can be prepared from aryltrimethylsilanes ArSiMea and acyl chlorides in the presence of AlCla Aryllithium and Grignard reagents react with iron pentacarbonyl to give aldehydes ArCHO. The reaction of CO with aryllithium may occur by electron transfer. ... 

Reaction of Grignard reagents with acyl chlorides. 363-364 aldehydes.. 361-.363, 655 aldimines. 366 367... 

Acid-catalyzed iminium ion 57 fonnation is followed by isocyanide 54 addition and capture of the remaining nitrilium ion 58 by the carboxylate of 56 to generate compound 59. A rapid O N acyl transfer takes then place in order to obtain dipeptide 60 as a mixture of epimers at C4. Although the control of the stereochanistry of the newly formed stereocenter still remains a problan of the Ugi reaction, it nicely demonstrates the force of the Ugi MCR, as all of the carbon atoms needed are successively assanbled in a single step [22], Mannich-type 4CR are often used for the synthesis of natural products. One example is the synthesis of the alkaloid ( )-roelactamine 65 (Scheme 6.6). The reaction of piperonal 61 with methylamine, Grignard reagent 62, and acid chloride 63 results in the formation of amide 64, which... 

Alkynyltrialkylborates are versatile intermediates to 1,4-dikelones and y-oxo-esters, -nitriles, and -alkynes, as well as substituted ketones. A route from a -unsaturated cycloalkenones to 1,4-diketones is available wherein an aldehyde undergoes photoaddition to the alkene unit, and a variety of 1,4-diones is obtained by thiazolium salt-catalysed addition of aldehydes to but-2-enone. Monoacetalized 1,4-diketones and y-keto-aldehydes are formed on reaction of acyl chlorides with the Grignard reagents (13) and (14), respectively. 

Scheme 4-242. Synthesis of ketones by iron-catalyzed reaction of acyl chlorides with Grignard reagents.

Now let s draw the forward scheme. Benzene is converted into bromobenzene upon treatment with Br2 and AlBrs (via an electrophilic aromatic substitution reaction). Bromobenzene is then converted to phenyl magnesium bromide (a Grignard reagent), which is then treated with formalddryde, followed by water work-up, to give benzyl alcohol. This alcohol then serves as a nucleophile in a subsequent acyl substitution reaction with acetyl chloride and pyridine to produce benzyl acetate (a process called acetylation). 

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