Grignard reagents pyridyl, reactions with

Generation of 3- and 4-Pyridyl Grignard Reagents and Reactions with Aldehydes and Ketones... 

In the reactions of 2-pyridyl sulfoxides with Grignard reagents (71CC649), benzylic groups tended to couple preferentially with the p-... 

A different type of reaction, in which the intermediate formation of a chelate ring is crucial, is the reaction of pyridyl thioates with Grignard reagents, which achieves an overall conversion of an alkyl or aryl halide to a ketone (Scheme 105).378 Grignard reactions are highly susceptible to chelation factors and stereoselectivity is observed in the addition of organomagnesium or... 

Fumkawa, N. Shibutani, T. Fujihara, H. Preparation of bipyridyl derivatives via a-lithiation of pyridyl phenyl sulfoxides, substitution with electrophiles and cross-coupling reactions with Grignard reagents. Tetrahedron Lett. 1989, 30, 7091-7094. 

The anti -stereocontrolled alkylative ring-opening reaction of azabicyclic alkenes has been reported.100 iV-(2-Pyridyl)sulfonylazabenzonorbornadiene (36) has reacted with Grignard reagents in the presence of catalytic amounts of CuCN to afford, in good yields and excellent anti selectivity, the corresponding dihydronaphthalene-1-amines (37) (Scheme 20). 

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