Raw materials and manufacturing processes

The concentration of biogenic amines in cheese could be used as an indicator for its freshness, and an indicator of the quality of the raw materials and manufacturing processes involved. 

By the design of the sampling procedure, the LGC, and the laboratories within the British tobacco industry, have reduced to an aceptable level the random variations associated with the raw material and manufacturing process. The variables associated with machine smoking and analysis have been largely eliminated by testing the samples in a... 

A considerable amount of (unpublished) work has been performed by Ciurczak on counterfeit tablets. Using the same algorithms that have been applied to discriminate between placebos and active products, counterfeit products may be easily identified. The spectral variability stems from different raw materials and manufacturing processes, even though the active may be present at the correct level. 

Quality assurance in the paint industry demands not only quality control of final products, but also a careful control of raw materials and manufacturing processes. Paint manufacturers require simple and fast analytical procedures for online control. It is important to obtain measurements directly from whole samples, without any prior treatment, and the incorporation of sample preparation techniques, such as supercritical fluid extraction or accelerated solvent extraction, which facilitate the separation of paint components prior to their analysis. 

To achieve quality assurance and control, it is critical to ensure the following checks are implemented throughout the raw material and manufacture process ... 

Hazard The ability of a substance to harm or produce adverse effects. In the context of our businesses, hazards may be associated with raw materials and manufacturing processes, product packaging, or use and foreseeable misuse (or any misuse) of our products. Hazards may be health hazards, physical or chemical hazards, or environmental hazards. 

For many botanical preparations, there are often uncertainties in the identity of the plant species and/or consistency of botanical raw materials. Complicated manufacturing processes add further possible variation to the drug substance and final products. While most contamination problems unique to botanicals are resolvable, purity/potency and stability are more difficult technical issues, without knowing the identity of active ingredients. 

Similar to unexplained fluctuations in stability profiles and OOS trends, changes to raw materials and in-process and finished product point to any number of problems related to the manufacturing train, process validation, supplier, or environment, and so on. The greatest variability in any product is presented by its raw materials, particularly when provided by an outside supplier. It is essential to establish a system that allows QC to frequently monitor the variability of all critical raw materials. The ability of QC to quickly detect even small shifts in a raw material s performance will allow... 

An expanded form of seizure is the mass seizure a draconian action that can and has brought companies to their knees. Mass seizures vary in scope, but the basic premise is that all goods at a certain location are misbranded and/or adulterated. Mass seizures and frequently made at the company s manufacturing facilities and include all raw materials and in-process... 

Global sourcing. Multinational companies (and many local ones) source raw materials and manufactured goods from suppliers located around the world. For economic or cultural reasons, not all of these suppliers use products or processes that are sustainable - a situation that can compromise the ethics of purchasers and can reduce the vendor s ability to provide a consistent supply of high-quality products. Because it considers a supplier s sustainability when it begins developing business partnerships, 3M is more likely to build relationships with responsible and reliable vendors. 

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