Rauvolfia

But that was only one half of the logic behind the chemical-imbalance theory. The other half came from studies of reserpine, a drug that was extracted from Rauvolfia serpentina or the Indian snakeroot plant, which had historically been used to treat snakebite, hypertension, insomnia and insanity. In studies of animals, reserpine was reported to induce sedation and to decrease brain levels of norepinephrine, serotonin and dopamine. Clinical reports indicated that some people became severely depressed when taking reserpine.14 Putting these two findings together, it seemed likely that reserpine made people depressed because it decreased neurotransmitter levels. 

D-tubocurarine from Chondrodendron tomentosum Ruiz et Pav. and Rauvolfia serpentina Benth. et Kurz and horse radish peroxidase 3 mg/ml, which prevent the peroxide formation, block the fruit formation as a whole, while yohimbine and gaillardine inhibit the seed formation. Neostigmine stimulates the fruit and seed yield, although its precursor physostigmine has no significant effect (Roshchina and Melnikova, 1998). 

KUTCHAN, T.M., HAMPP, N., LOTTSPEICH, F., BEYREUTHER, K., ZENK, M.H., The cDNA clone for strictosidine synthase from Rauvolfia serpentina - DNA sequence determination and expression in Escherichia col., FEBSLett., 1988, 237,40-44. 

HAMPP, N., ZENK, M.H., Homogeneous strictosidine synthase from cell suspension cultures of Rauvolfia serpentina, Phytochemistry, 1988,27, 3811-3815. 

KUTCHAN, T.M., Expression of enzymatically active cloned strictosidine synthase from the higher plant Rauvolfia serpentina in Escherichia coli, FEBS Lett., 1989, 257, 127-130. 

Ruppert, M., Woll, J., Giritch, A., Genady, E., Ma, X. Y. and Stockigt, J. 2005. Functional expression of an ajmaline pathway-specific esterase from Rauvolfia in a novel plant-virus expression system. Planta, 222(5) 888-898. 

Ruppert, M., Panjikar, S., Barleben, L. and Stockigt, J. 2006. Heterologous expression, purification, crystallization and primary X-ray analysis of raucaffricine glu-cosidase, a plant enzyme specifically involved in Rauvolfia alkaloid biosynthesis. Acta Crystallographica Section F-Structural Biology and Crystallization Communications, 62 257-260. 

Bracher, D. and Kutchan, T. M. 1992. Strictosidine synthase from Rauvolfia serpentina Analysis of a gene involved in indole alkaloid biosynthesis. Archives of Biochemistry and Biophysics, 294 717-723. 

Reserpine Alkaloid Antihypertensive (reduces blood pressure) Rauvolfia serpentina (Indian snakeroot)... 

Rauvolfia verticilata (Lour.) Baill. Luo Fu Mu (root) Reserpine, rescinnamine, beta-sitosterol, aricine, vellosimine, peraksine, serpentine, robinin.33-39-510 Treat hypertension, psychosis, schizophrenia. 

N.A. Rauvolfia serpentina (L.) Benth. Indole alkaloids, reserpine, rescinnamine, ajmaline, yohimbine.99 Regulate hearbeat, treat high blood pressure and anxiety. Sedative and depressant effect on sympathetic nervous system. 

Cucumis sativus, Dioscorea opposita, D. batatus, Dolichos lablab, Litchi chinensis Solanum lyratum, S. melongen Rauvolfia verticilata... 

Phaseolus angularis, P. lunatus, P radiatus, P vulgaris, Pueraria lobata, P. pseudo-hirsuta, Rauvolfia verticilata... 

Rauvolfia serpentina, Strychnos nux-vomica Cannabis sativa... 

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