Rationally designed drug

An overall appreciation of the principles of clinical pharmacology will also allow one to rationally design drugs with desirable pharmaceutical properties such as enhanced stability and activity, and a favorable disposition profile. In addition... 

While the number of known protein structures is expanding exponentially, a corresponding increase in the number of rationally designed drugs has not occurred. The paucity of rationally designed drugs is... 

Rating programs Rational design Rational drug discovery Rauwolfia serpentina Rauwolscine [131-03-3]... 

Rational design, 148-149, 152 Real-time assays, 83, 88 Receptor(s). See also Drug receptors affinity for, 6, 63 allosteric model of, 143 Clark s work, 3 classical model of, 44-45 concept of, 2-4 conformations, 13-14, 13 Of conservation equation for, 76 constitutive activity of, 49-51 coupling of, 27 definition of, 2 desensitization of, 34 efficacy for, 6... 

There are various ways in which CMEs can benefit analytical applications. These include acceleration of electron-transfer reactions, preferential accumulation, or selective membrane permeation. Such steps can impart higher selectivity, sensitivity, or stability to electrochemical devices. These analytical applications and improvements have been extensively reviewed (35-37). Many other important applications, including electrochromic display devices, controlled release of drugs, electrosynthesis, and corrosion protection, should also benefit from the rational design of electrode surfaces. 

Boyd DB. Innovation and the rational design of drugs. CHEMTECH 1998 28 (5) 19-23. 

Catalyzed by the progress made in sequencing the human genome, the new field of pharmacogenomics offers the promise of being able to make available a host of new rationally designed, safer drugs. 

Furthermore, polymantanes have the potential to be utilized in the rational design of multifunctional drug systems and drug carriers. In host-guest chemistry, there is plenty of room for working with diamondoids. 

Computational approaches towards the rational design of drug-like compound libraries. Comb. Chem. High-Throughput Screen. 2001, 4, 453 75. 

Matter, H., Baringhaus, K. H., Naumann, T., Kiabunde, T., Pirard, B., Computational approaches towards the rational design of drug-like compound libraries, Comb. Chem. High Throughput Screen. 2001, 4, 453-475. 

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