Drugs multifunctional

Torchilin, V. P. (2006). Multifunctional nanocarriers. Advanced Drug Delivery Reviews, Vol. 58, 14, (December 2006), pp. (1532-1555), ISSN 0169-409X Tran, V. T., Benoit, J. P. Venier-Julienne, M. C. (2011). Why and how to prepare biodegradable, monodispersed, polymeric microparticles in the field of pharmacy International Journal of Pharmaceutics, Vol. 407,1-2, (December 2011), pp. (1-11), ISSN 0378-5173... 

The nanostructured molecular arrangements from DNA developed by Seeman may find applications as biological encapsulation and drug-delivery systems, as artificial multienzymes, or as scaffolds for the self-assembling nanoscale fabrication of technical elements. Moreover, DNA-protein conjugates may be anticipated as versatile building blocks in the fabrication of multifunctional supramolecular devices and also as highly functional-... 

Furthermore, polymantanes have the potential to be utilized in the rational design of multifunctional drug systems and drug carriers. In host-guest chemistry, there is plenty of room for working with diamondoids. 

Recent developments in polymer chemistry have allowed for the synthesis of a remarkable range of well-defined block copolymers with a high degree of molecular, compositional, and structural homogeneity. These developments are mainly due to the improvement of known polymerization techniques and their combination. Parallel advancements in characterization methods have been critical for the identification of optimum conditions for the synthesis of such materials. The availability of these well-defined block copolymers will facilitate studies in many fields of polymer physics and will provide the opportunity to better explore structure-property relationships which are of fundamental importance for hi-tech applications, such as high temperature separation membranes, drug delivery systems, photonics, multifunctional sensors, nanoreactors, nanopatterning, memory devices etc. 

Fig. 4.3. Studies of specific drug transport routes in multifunctional cell models such as Caco-2 may be complicated, since there is a lack of specific substrates for many drug transporters. Therefore, specialised cell...

Hatakeyama H, Akita H, Harashima H (2011) A multifunctional envelope type nano device (MEND) for gene delivery to tumours based on the EPR effect a strategy for overcoming the PEG dilemma. Adv Drug Deliv Rev 63 152-160... 

Fig. 10 Multifunctional solid biodegradable PLGA nanoparticles attached to several moieties such as T-cell antibodies, magnetic resonance contrast agent (biotin-BSA-Gd-DTPA) and encapsulated immunosuppressive drug (doxorubicin). (Adapted from [48])...

Liong M, Angelos S, Choi E, Patel K, Stoddart JF, Zink JI (2009) Mesostructured multifunctional nanoparticles for imaging and drug delivery. J Mater Chem 19 6251-6257... 

The failure in increasing residence time of mucoadhesive systems in the human intestinal tract has led scientists to the evaluation of multifunctional mucoadhesive polymers. Research in the area of mucoadhesive drug delivery systems has shed light on other properties of some of the mucoadhesive polymers. One important class of mucoadhesive polymers, poly(acrylic acid) derivatives, has been identified as potent inhibitors of proteolytic enzymes [72-74]. The interaction between various types of mucoadhesive polymers and epithelial cells has a direct influence on the permeability of mucosal epithelia by means of changing the gating properties of the tight jrmctions. More than being only adhesives, some mucoadhesive polymers can therefore be considered as a novel class of multifunctional macromolecules with a number of desirable properties for their use as delivery adjuvants [72,75]. 

Youdim, M.B.H. (2006) The path from anti Parkinson drug selegiline and rasagiline to multifunctional neuroprotective anti... 

Torchilin VP (2006) Multifunctional nanocariiers. Adv Drug Dehv Revs 58 1532-1555... 

Additional information <1> (<1> multifunctional deoxynucleoside kinase of insect cells is a target for development of new highly selective insecticidial drugs [5]) [5]... 

Examples of multifunctional sulfides which bond to platinum(II) via the sulfide sulfur are phenoxathiin (184) and the phenothiazine drugs (185).1732,1733... 

---