Rationale results

Mitchell MS, Harel W, Kan-Mitchell J, et al. Active specific immunotherapy of melanoma with allogeneic cell lysates. Rationale, results, and possible mechanisms of action. Ann NY Acad Sci 1993 690 153-166. 

The quantum phase factor is the exponential of an imaginary quantity (i times the phase), which multiplies into a wave function. Historically, a natural extension of this was proposed in the fonn of a gauge transformation, which both multiplies into and admixes different components of a multicomponent wave function [103]. The resulting gauge theories have become an essential tool of quantum field theories and provide (as already noted in the discussion of the YM field) the modem rationale of basic forces between elementary particles [67-70]. It has already been noted that gauge theories have also made notable impact on molecular properties, especially under conditions that the electronic... 

Let s use a simple example to develop the rationale behind a one-way ANOVA calculation. The data in Table 14.7 show the results obtained by several analysts in determining the purity of a single pharmaceutical preparation of sulfanilamide. Each column in this table lists the results obtained by an individual analyst. For convenience, entries in the table are represented by the symbol where i identifies the analyst and j indicates the replicate number thus 3 5 is the fifth replicate for the third analyst (and is equal to 94.24%). The variability in the results shown in Table 14.7 arises from two sources indeterminate errors associated with the analytical procedure that are experienced equally by all analysts, and systematic or determinate errors introduced by the analysts. 

The rationale of this definition of a solution will become clear in the sequel. Observe that the operator L is pseudomonotone (see a definition in Section 1.2) but is not coercive on U. Therefore, solvability of problem (3.98) does not follow from known results. 

Adequate support from the facility staff is absolutely essential. The facility staff must help the analysis team gather pertinent documents (e.g., PSilDs, procedures, software descriptions, material inventories, meteorological data, population data) and must describe current operating and maintenance practices. The facility staff must then critique the logic model(s) and calculation(s) to ensure that the assumptions are correct and that the results seem reasonable. The facility staff should also be involved in developing any recommendations to reduce risk so they will fully understand the rationale behind all proposed improvements and can help ensure that the proposed improvements are feasible. Table 12 summarizes the types of facility resources and personnel needed for a typical QRA. 

When rotation occurs, static imbalance translates into a centrifugal force. As a result, this type of imbalance is sometimes referred to as force imbalance and some balancing machine manufacturers use the word force instead of static on their machines. However, when the term force imbalance was just starting to be accepted as the proper term, an American standardization committee on balancing terminology standardized the term static instead of force. The rationale was that the role of the standardization committee was not to determine and/or correct right or wrong practices, but to standardize those currently in use by industry. As a result, the term static imbalance is now widely accepted as the international standard and, therefore, is the term used in this chapter. 

Methyl 2,7- and 3,6-dimethyl-l//-azepine-1-carboxylate also show marked differences towards acid hydrolysis. The 3,6-dimethyl isomer, with 10% sulfuric acid at 20°C, forms the expected A,-(ethoxycarbonyl)-2,5-dimethylaniline in high yield (82%) however, the 2,7-dimethyl isomer requires more forcing conditions to effect ring contraction and yields a mixture of A-(methoxycarbonyl)-2,6-dimethylaniline (16% mp 103-105°C), A-(methoxycarbonyl)-2,3-dimethylaniline (1% mp 90-92°C), 2,6-dimethylphenol (1%), and 3,4-dimethylphenol (6% mp 66-67 C).115 A mechanistic rationale for these results has been proposed. 

Thermolysis of the azide 15, bearing an allyl side chain, is more complex, and in addition to ethyl 4-allylindole-2-carboxylate and ethyl 4-methyl-l//-3-benzazepine-2-carboxylate (16 oil), two unstable tricyclic aziridines 17 and 18 are produced.82 A mechanistic rationale for these results has been suggested. 

The 2-(2-pheriylvinyl) derivative 18 and the thienyl compound 20 cyclize exclusively at the alkene carbon, and at the thiophene ring, to give 3,4-diphenyl-l//-2-benzazepine (19) and 4-phenyl-6-//-thieno[3,2-e]-2-benzazepine (21), respectively.48 A mechanistic rationale for these results has been offered. This method has been extended to the synthesis of 7Z7-pyrido[3,4-t/]-, 7//-pyrido[2,3-t/]- and 77/-pyrido[4,3-r/]benzazepincs and to other thieno- and furo-fused 2-benzazepines.244... 

Making public the rationale underlying the choice of mentees -it has to be one that will satisfy most employees in the sense that they will feel equally valued as a result. 

The rationale behind this choice of bond integrals is that the radical stabilizing alpha effect of such radicals are explained not by the usual "resonance form" arguments, but by invoking frontier orbital interactions between the singly occupied molecular orbital of the localized carbon radical and the highest occupied molecular orbital (the non-bonding electrons atomic orbital) of the heteroatom (6). For free radicals the result of the SOMO-HOMO interaction Ts a net "one-half" pi bond (a pi bond plus a one-half... 

---