Research rational drug

Goodford P.J.(1998) Atom movements during drug-receptor interactions, in Rational Molecular Design in Drug Research, (eds Liljefors,T., Jorgensen, F.S. 

J. L. Fauchere, Elements for the Rational Design of Peptide Drugs , in Advances in Drug Research , Vol. 15, Ed. B. Testa, Academic Press, London, 1986, p. 29-69. 

In fact, QSAR has now become one of the most powerful tools of rational drug design, an approach that is used in the development of a host of new products in pharmacy and other fields of biological research. 

Kubinyi, H. (1999) Chance favors the prepared mind—from serendipity to rational drug design../. Recep. Signal Transduc. Research 19, 15-39. 

This expense is a strong motivation for medical researchers to develop a more efficient means of drug discovery than the old trial-and-error method. Rational drug discovery is the name given to techniques that employ the principles of chemistry and physics, or are guided by experimental data, to aid in the search for new drugs. 

N. C. Cohen (1983). Towards the rational design of new leads in drug research. Trends Pharmacol. Sci. 4 503-506. 

Method Genomics, traditional biomedical research Animal models, in vitro assays Rational drug design, high throughput screening, combinatorial chemistry Medicinal chemistry In vivo assays, animal models I N D Healthy human volunteers Patients N Patients D A... 

Rational drug design Me too drugs Folk medicine Molecular modeling Planned research Natural product... 

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