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Randomized trial external effectiveness

Evidence from at least one randomized controlled trial (level I) show that 10% urea is effective for the treatment of psorisasis, ichthyosis, and dry feet, and 4 to 10% for the treatment of dry atopic skin and senescent skin. Evidence from another well-designed clinical study (level II) supports the treatment of hand dermatitis with urea. Evidence at level I also exist showing barrier improving effects of urea in both normal and in dry skin disorders (atopic skin, ichthyosis). Furthermore, strong evidence exists (level I) for reduced susceptibility to SLS, but not to other external agents. No evidence has been found for successful treatment of seborrhoic dermatitis, perioral dermatitis, and keratosis pilaris with urea. [Pg.221]

The external validity refers to applicability and generalization and is outlined in the section, Applying the Results. The remainder of this section focuses on critically appraising the quality— that is, the internal validity—of individual trials. The internal validity is determined by how well the trial ensures that the known and unknown risk factors are equally distributed between the treatment and control groups. To ensure validity, the conduct of the trial should minimize systematic bias and random error as much as possible to provide results that are as accurate and close to the truth as possible. Four sources of bias are possible in trials of health care interventions selection bias, performance bias, attrition bias, and detection bias. Bias can result in an overestimation or underestimation of the effectiveness of a drug therapy and mislead the reader. While it is beyond... [Pg.31]


See other pages where Randomized trial external effectiveness is mentioned: [Pg.78]    [Pg.228]    [Pg.228]    [Pg.3040]    [Pg.162]    [Pg.304]    [Pg.16]    [Pg.150]    [Pg.263]   


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External Effects

Random effects

Randomization (randomized trials

Randomized trial external

Randomized trial external effects

Randomized trial external effects

Randomized trial external trials

Randomized trials

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