Rabies virus viral proteins

As noted previously, enveloped animal viruses are surrounded by an outer phospholipid layer derived from the plasma membrane of host cells and containing abundant viral glycoproteins. The processes of adsorption and release of enveloped viruses differ substantially from these processes In nonenveloped viruses. To Illustrate lytic replication of enveloped viruses, we consider the rabies virus, whose nu-cleocapsld consists of a single-stranded RNA genome surrounded by multiple copies of nucleocapsld protein. Like... 

An insight into the mode of action of this drug is possibly given by the following work. When pseudo-rabies virus was exposed to lUdR, most of the thymine in the viral DNA was replaced by 5-iodouracil. The virus, when allowed to infect cultured mammalian kidney cells, continued to produce DNA, but this did not become protein-coated and hence did not generate new virus particles. That the new DNA was potentially infective was then shown by exposing it to thymidine when much of the iodouracil had been replaced by thymine, infectivity was restored (Kaplan and Ben-Porat, 1966). 

RNA viruses Viral RNA enters the cell and uses the cell s machinery to produce the proteins and enzymes that the virus requires to reproduce itself. (Examples influenza, measles, mumps, rubella, colds, meningitis, rabies, yellow fever). 

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