Rabbits pulmonary

Nichols WK, Covington MO, Seiders CD, et al. 1992. Bioactivation of halogenated hydrocarbons by rabbit pulmonary cells. Pharmacol Toxicol 71 335-339. 

FIG. 3. Extensive SR network stained with osmium ferricyanide in a smooth muscle cell of the rabbit pulmonary artery. Note the variable morphology of the network with tubules, fenestrated sheets seen enface (small arrows) or stacks of fenestrated sheets (large arrow) as well as surface couplings where the SR apposes the plasma membrane. M, mitochondria. (From Nixon et al... 

Mathews JM, Bend JR. N-alkylaminobenzotriazoles as isozyme-selective suicide inhibitors of rabbit pulmonary microsomal cytochrome P-450. Mol Pharmacol 1986 30(l) 25-32. 

Philpot, R. M., Arinc, E. and Fouts, J. R. Reconstitution of the rabbit pulmonary mixed-function oxidase system from solubilized components. Drug Metab. Dispos. (1975) 3 118-126. 

G115 extract protects rat heart from iechemia-reperfusion injury G115 extract protects rabbits pulmonary artery from free radical injury G115 extract inhibita dose-dependently lipid peroxidation in rats Activation of the superoxide dismutase gen by Rb2 Scavenging effect of hydroxyl radicals, protection of fatty acids Anti free radical action of Ginsenosides Rb1, Rb2, Rb3, Rc, Rd in rats Antioxidant action in rats (SOD, catalase, glutathionperoxidase)... 

Figure 16.14 represents a summary of the most important studies performed in the field of free radical scavenging effects. G115 inhibits lipid peroxidation in rats. It protects the rabbit pulmonary artery from free radical injury and the rat heart from ischemia reperfusion injury. Figure 16.15 illustrates the various diseases that are due to an excessive production of free radicals, such as atheroclerosis, diabetes, rheumatoid arthritis, and aging. 

Inhibited induced contractions of isolated rabbit pulmonary artery similarly to verpamil 640... 

In general, the MC2 receptor is Gs protein-coupled (Table 1), and two studies in the rabbit pulmonary artery indicate that this is also true for the presynaptic receptor. The evidence is, indirect, however, in that it suggests activation of adenylyl cyclase, the typical transduction step downstream from Gs. In the study by Gothert and Hentrich (1984), the facilitatory effect of ACTH was increased by simultaneous administration of forskolin, an activator of the catalytic subunit of adenylyl cyclase, and AH 21-132, a phosphodiesterase inhibitor. In the study by Costa and Majewski (1988), the facilitatory effect of ACTH was occluded when the vessel was super-fused with a lipid-soluble cAMP analogue. 

Serabjit-Singh, C.J. Wolf, C.R. and Philpot, R.M. The rabbit pulmonary monoxygenase system Immunochemical and biochemical characterization of enzyme components. J Biol Chem 254 9901-9907, 1979. 

Starke, K., Montel, H., Gayk, W., Merker, R., 1974. Comparison of the effects of clonidine on pre- and postsynaptic adrenoceptors in the rabbit pulmonary artery. Naunyn-Schmiedeberg s Arch. Pharmacol. 285, 133-150. 

Molderings, G.J., Hentrich, F., Gdthert, M., 1991. Pharmacological characterisation of the imidazoline receptor which mediates inhibition of noradrenaline release in the rabbit pulmonary artery. Naunyn-Schmiedberg s Arch. Pharmacol. 344, 630-638. 

Aminopyridine (4-AP) may be the most selective inhibitor of Ky channels in vascular smooth muscle (Table I). For this reason, 4-AP can be used to separate Ky currents from K a currents, which are also activated by membrane depolarization (see Fig. lA) (Beech and Bolton, 1989b Gelband and Hume, 1992 Ishikawa et al., 1993 Okabe et al., 1987 Robertson and Nelson, 1994 Smirnov and Aaronson, 1992 Volk and Shibata, 1993). Measured half-inhibition constants (Kj) are 300 x.M in rabbit pulmonary artery at -FlO mV (Okabe et al., 1987), about 1.1 mA4 in human mesenteric artery at -1-60 mV (Smirnov and Aaronson, 1992), and 700 p.M in canine renal artery at -1-10 mV (Gelband and Hume, 1992). 4-AP does not affect K a or K[r channels in this concentration range, but may inhibit K, jp currents to some extent (Quayle et al., 1993b) (Table I). 

Mathews, J.M. and J.R. Bend (1993). N-Aralkyl derivatives of 1-aminobenzotriazole as potent isozyme-selective mechanism-based inhibitors of rabbit pulmonary cytochrome P450 in vivo. J. Pharmacol. Exp. Then 265, 281—285. 

N. Yokotani, Y. Fujii-Kuriyama, M. Haniu et al. (1987). cDNA cloning and inducible expression during pregnancy of the MRNA for rabbit pulmonary prostaglandin w-hydroxylase (cytochrome P-450p-2). J Biol. Chem. 62, 13366-13371. 

Other studies have discounted a prejunctional effect of NO on NE release from sympathetic nerve endings. In this context neither NO, supplied as acidified nitrite to the transmurally stimulated guinea pig pulmonary artery (Cederqvist and Gustafsson, 1994) or endogenously released by acetylcholine in the mesenteric artery of the dog (Toda et al., 1990), nor the prevention of NO synthesis with NNA and N -nitro-L-arginine methyl ester in the rabbit pulmonary artery (Schinozuka et al., 1992) and the rat tail artery (Thorin and Atkinson, 1994), nor its destruction with hemoglobin in the coronary vessels of the isolated rabbit heart (Wennmalm et al., 1989) were found to affect NE release. 

Shinozuka, K., Kobayashi, Y., Shimoura, K., and Hattori, K. (1992). Role of nitric oxide from the endothelium on the neurogenic contractile responses of rabbit pulmonary artery. Eur. J. Pharmacol. 222, 113-120. 

Himpens B, Kitazawa T, Somlyo AP (1990) Agonist dependent modulation of the Ca sensitivity in rabbit pulmonary artery smooth muscle. Eur J Physiol 417 21-28 Himpens B, Matthijs G, Somlyo AP (1989) Desensitization to cytoplasmic Ca and Ca sensitivities of guinea-pig ileum and rabbit pulmonary artery smooth muscle. J Physiol (London) 413 489-503... 

Recently, it was shown that inositol trisphosphate could induce calcium release and vasoconstriction in permeabilized rabbit pulmonary artery. Perhaps, as in the platelet, the TXA2/PGH2 receptor is coupled to phosphatidyl-inositol polyphosphate turnover. 

Salzman PM, Salmon JA and Moncada S Prostacyclin and thromboxane Ao synthesis by rabbit pulmonary artery. Submitted for publication, 1 0. 

Zeldin DC, Plitman JD, Kobayashi J, Miller RF, Snapper JR, Falck JR, Szarek JL, Philpot RM, Cap-devila JH (1995) The rabbit pulmonary cytochrome P450 araehidonic acid metabolic pathway characterization and significance. J Clin Invest 95 2150-2160... 

Zhu D, Bousamra M 2nd, Zeldin DC, Falck JR, Townsley M, Harder DR, Roman RJ, Jacobs ER (2000) Epoxyeieosatrienoic acids constrict isolated pressurized rabbit pulmonary arteries. Am J Physiol Lung Cell Mol Physiol 278 L335-L343... 

Dunn, D. M., and Franzblau, C., 1982, Effects of ascorbate on insoluble elastin accumulation and crosslink formation in rabbit pulmonary artery smooth muscle cultures. Biochemistry 18 4195-4202. 

Zheng XF, Chen LF, Bian RL 1983 Effect of a-terpineol on rabbit pulmonary artery. Zhejiang Yike Daxue Xuebao 16 293-295, 285... 

Osipenko ON, Evans AM, Gurney AM. Regulation of the resting potential of rabbit pulmonary artery myocytes by a low threshold, 02-sensing potassium current. Br J Pharmacol 1997 120 1461-1470. 

Thuringer D, Findlay I. Contrasting effects of intracellular redox couples on the regulation of maxi-K" channels in isolated myocytes from rabbit pulmonary artery. J Physiol 1997 500 583-592. 

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