Quinuronium

Quinuronium is a complex urea compound (Fig. 5.7) widely used in Babesia infections in horses, cattle, sheep, and swine. The drug is administered only subcutaneously at dosages of 0.3-0.5 mg/kg bw in horses and 0.5 mg/kg bw in cattle, sheep and swine. 

Amicarbalide, chromonar, dyclonine, gliben-clamide, levallorphan, metocurine, padimate, propanidid, quinuronium, salinazid... 

Chloroquine Phosphate 566.6 Quinuronium Sulphate 671.8 Ergotoxine Esylate... 

Diquat Dibromide Distigmine Bromide Ethyl Nicotinate Gallamine Triethiodide Hexamethonium Bromide Hydrastinine Mebezonium Iodide Neomycin Noradrenaline Paraquat Dichloride Pentolinium Tartrate Quinuronium Sulphate Streptomycin Tubocurarine Chloride... 

Quinuronium sulfate is a bitter, white to yellow, crystalline powder that is usually available as a stable 5% aqueous solution. This compound is effective in the treatment of B. caballi infections but is associated with relapses, making it more effective for premunition than for the elimination of infection. One treatment consists of two doses of a 5% solution of quinuronium sulfate, administered s.c. at 0.3mg/kg, 6h apart. Quinuronium sulfate has a narrow margin of safety and overdosing produces parasympathomimetic effects including tremors, salivation, urination and defecation. These signs usually respond to treatment with atropine, epinephrine (adrenaline) and calcium gluconate. The interval between treatments should not be shorter than 2 weeks and should preferably be 3 months because sensitization occurs, which results in shock, with a profound drop in blood pressure, and death. 

Babesiasis Babesia spp. Trypan blue, acriflavine hydrochloride, quinuronium sulphate, dimi-nazene, pentamidine, phenamidine, imicarbalide, imidocarb, primaquine, oxytetracycline, chlortetracycline, clindamycin. 

The entire molecular disposition of suramin does not appear to be essential for activity. It has been reported that the N,N -diphenylurea derivatives retain the biological activity to a large extent [2,6]. Consequently a number of N,N -diarylureas were evaluated for their antiprotozoal activity and as a result amicarbanilide (4), imi-docarb (5), nicarbazine [a complex formed from N,N -bis(4-nitrophenyl)urea (6) and 4,6-dimethyl-2-hydroxyprimidine (7)] and quinuronium sulphate (8) were found to exhibit high activity against babesiasis in domestic animals [2,7]. 

Crystals from pyridine, mp 262°. Sot in di] acid. Bismethosulfate, C H NjC Sj, 6,6 ureylenebis[l,r-dt-methylquinolinium] sulfate, quinuronium sulfate, 6,6 -ure-ytenebisil-methylquinolinium)bis(methosulfate), dimethyl quinoiyt methyisulfate urea, SN 5870, Acaprin, Zolhelone, Baburan, Pirevan, Pyropiasmin, Atral. Yellow crystals from methanol, dec 237°. Freely sol in water. therap cat (vet) Antiprotozoal (Babesia). 

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