Quinuronium sulfate

Quinuronium sulfate is a bitter, white to yellow, crystalline powder that is usually available as a stable 5% aqueous solution. This compound is effective in the treatment of B. caballi infections but is associated with relapses, making it more effective for premunition than for the elimination of infection. One treatment consists of two doses of a 5% solution of quinuronium sulfate, administered s.c. at 0.3mg/kg, 6h apart. Quinuronium sulfate has a narrow margin of safety and overdosing produces parasympathomimetic effects including tremors, salivation, urination and defecation. These signs usually respond to treatment with atropine, epinephrine (adrenaline) and calcium gluconate. The interval between treatments should not be shorter than 2 weeks and should preferably be 3 months because sensitization occurs, which results in shock, with a profound drop in blood pressure, and death. 

Crystals from pyridine, mp 262°. Sot in di] acid. Bismethosulfate, C H NjC Sj, 6,6 ureylenebis[l,r-dt-methylquinolinium] sulfate, quinuronium sulfate, 6,6 -ure-ytenebisil-methylquinolinium)bis(methosulfate), dimethyl quinoiyt methyisulfate urea, SN 5870, Acaprin, Zolhelone, Baburan, Pirevan, Pyropiasmin, Atral. Yellow crystals from methanol, dec 237°. Freely sol in water. therap cat (vet) Antiprotozoal (Babesia). 

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