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Quinol system

In the reduction or oxidation of quinone/ quinol systems, free radicals also appear as intermediate steps, but these are less reactive than flavin radicals. Vitamin E, another qui-none-type redox system (see p.l04), even functions as a radical scavenger, by delocalizing unpaired electrons so effectively that they can no longer react with other molecules. [Pg.32]

Wang, J. Pettus, L. H. Pettus, T. R. R. Cycloadditions of o-quinone dimethides with p-quinol derivatives regiocontrolled formation of anthracyclic ring systems. Tetrahedron Lett. 2004, 45, 1793-1796. [Pg.116]

Intramolecular [n2 + 2] photocycloadditions are equally numerous and many have considerable synthetic potential. 4-(But-3-enyloxy)quinol-(l//)2-one (254), for example, is converted into a mixture of isomeric adducts 255 and 256 on irradiation in methanol.208 Intramolecular cycloaddition has also been observed in the pyrimidinedione 257209 and in the dehydrovaline acrylamide 258 which on irradiation in dioxane affords the novel /1-lactam system 259.210... [Pg.281]

At this point the oxidation stage of quinonediimine has been fully reached its (very unstable) salts have scarcely any colour. The production of colour only takes place when quinonoid and benzenoid systems are present together. The molecular union of the two substances at different stages of oxidation produces the intense absorption which is a prerequisite for the formation of a dye (Willstatter and Piccard). This union need not take place in the proportion 1 1, which obtains in the present case. The relations between quinhydrone and quinone-quinol are quite similar (p. 314). [Pg.319]

L-Tryptophan was used for the synthesis of octahydroindolo[2,3-a]quinol-izines 147 (64CB2463 74CPB2614 81JOC4914), and the tetracyclic system 148 was obtained from a-AAs and 4-chloro-6,7-dihydro-5//-pyrimido[5,4-d][l]benzazepine (93JHC233). [Pg.61]

Aromatic hydroxylation. Aromatic hydroxylation such as that depicted in Figure 4.3 for the simplest aromatic system, benzene, is an extremely important bio transformation. The major products of aromatic hydroxylation are phenols, but catechols and quinols may also be formed, arising by further metabolism. One of the toxic effects of benzene is to cause aplastic... [Pg.83]

Oxidative phenolic coupling.1 The vancomycin antibiotics are polypeptides with bridging diphenyl ether groups. Evans et al. have shown in model systems such as 1 that cyclization to o-halophenolic peptides (2) can be accomplished by oxidation with thallium(III) nitrate in THF-methanol or CH2Cl2-methanol followed by CrCl2 reduction of a para-quinol intermediate (a). In three cases the yield of cyclic products was 40-48%. [Pg.326]

With water, the reaction was carried out in aqueous acetonitrile at 0°C, but the products (p-quinols) were formed in moderate yield better results were obtained with silylated phenols, especially with their tripropylsilyl ethers [13]. For fluorina-tion, pyridinium polyhydrogen fluoride was the source of fluoride this system was effective with a variety of substrates, including a phenolic steroid [15]. As with DIB, intramolecular cyclizations were also performed on several occasions. [Pg.56]

The ability of the cydohexa-2,4-dienone unit of ortbo-quinone monoketals and other ortho-quinol derivatives to react as either a diene or a dienophile component in [An+2n cydoadditions is arguably their prindpal virtue in organic synthesis, and paradoxically it is also the prindpal reason why it is often difficult to exploit them in synthesis they often dimerize faster than they can combine with another -system partner. Adler, Andersson, and coworkers have extensively studied the behavior of ortbo-quinols in Diels-Alder cydoadditions,... [Pg.554]

Cua centers exist in two redox states [Cu(II)Cu(I)] and [Cu(I)Cu(I)]. The oxidized species is a fully delocalized mixed-valence pair (formally two Cu+ 1.5 ions), as revealed by EPR spectroscopy (Kroneck et al., 1988, 1990). Despite the similar coordination geometry around copper, these systems display sharper NMR lines than do the BCP due to a shorter electron relaxation time of the paramagnetic center (wlO "s) (dementi and Luchinat, 1998). NMR studies are available for the native Cua centers from the soluble fragments of the The. thermophilus, Paracoc-cus denitrificans, Paracoccus versutus, and Bacillus subtilis oxidases (Bertini et al., 1996 Dennison et al., 1995 Luchinat et al., 1997 Salgado et al., 1998a) and Pseudomonas stutzeri N2O reductase (Holz et al., 1999), as well as for engineered Cua sites in amicyanin (Dennison et al., 1997) and Escherichia coli quinol oxidase (Kolczak et al., 1999). [Pg.435]

Cyt b-c complex forms the evolutionary link betw.een the respiratory and photosynthetic electron-transport pathways [3]. In both systems it oxidizes quinols and reduces metalloproteins while generating protonmotive force. In cyanobacteria, the Cyt /jg-/complex is shared by both respiration and photosynthesis [21]. [Pg.214]

Quinones are cyclic unsaturated diketones in which the carbon atoms are derived from the oxidation of an aromatic system. Although the underlying reactivity of quinones is that of unsaturated ketones (cyclohexadi-enediones), it is tempered by this relationship to aromatic compounds and in particular by their reduction to dihydroxyphenols (quinols). [Pg.90]

S. acidocaldarius (strain 7) contains a cyanide-sensitive cytochrome oxidase [24], The purified cytochrome (M, 150000) is composed of three subunits (M, 37000, 23 000, and 14000). Difference spectra following reduction with dithionite show a Soret band at 441 nm and a maximum at 603 nm characteristic of aa3-type cytochromes. In addition, there is a band at 558 nm whose connection to the oxidase is not clear. This oxidase is stimulated by cholate, but unlike the oxidase from the DSM 639 strain it is inhibited by low concentrations of cyanide (pM as opposed to mM) and oxidizes horse-heart cytochrome c, TMPD-ascorbate, and caldariella quinol. The rates of oxidation (pmol/min/mg protein) for cytochrome c, TMPD-ascorbate, and quinol are 63, 6.1, and 0.2, respectively. Another cytochrome oxidase that has an absorption maximum at 602 nm, oxidizes caldariella quinol, but does not oxidize cytochrome c, is also present in strain 7 so that the terminal portion of the electron transport system in S. acidocaldarius consists of at least three oxidases. It is suggested [8] that the presence of three oxidases in 5. acidocaldarius is unlikely and that the cyanide-sensitive oxidase was isolated from a different species, namely S. solfataricus. There is little taxonomic information in this assertion to judge whether strain 7 and DSM 639 are indeed different species. However, based on growth conditions reported by the investigators [12,28], which are unique for S. acidocaldarius and S. solfataricus [ 22, there is no reason to suspect that these organisms are different species. [Pg.313]


See other pages where Quinol system is mentioned: [Pg.564]    [Pg.564]    [Pg.338]    [Pg.150]    [Pg.536]    [Pg.670]    [Pg.431]    [Pg.706]    [Pg.541]    [Pg.440]    [Pg.120]    [Pg.103]    [Pg.295]    [Pg.49]    [Pg.1026]    [Pg.64]    [Pg.388]    [Pg.46]    [Pg.158]    [Pg.541]    [Pg.542]    [Pg.550]    [Pg.555]    [Pg.558]    [Pg.560]    [Pg.564]    [Pg.566]    [Pg.99]    [Pg.223]    [Pg.39]    [Pg.440]    [Pg.359]    [Pg.93]    [Pg.2143]    [Pg.296]    [Pg.887]    [Pg.888]    [Pg.509]   
See also in sourсe #XX -- [ Pg.32 ]




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