Quinidine Heparin

Albumin, aminophylline, aspirin, heparin, insulin, metoclopramide, NSAIDs, muromonab-CD3 (OKT3), opiates, penicillins, propafenone, quinidine, senna, sulfonamide antimicrobials, and vancomycin... 

Abciximab, aminophylline, amiodarone, amrinone, aspirin, carbamazepine, chlorpromazine, danazol, diltiazem, eptifi-batide, heparin, histamine2-receptor antagonists, low molecular weight heparins, methyldopa, milrinone, procainamide, quinidine, quinine, NSAIDs, thiazide diuretics, ticlopidine, tirofiban, and valproic acid... 

Type II IgG Hemolytic anemia, thrombocytopenia Quinidine, methyldopa, penicillins, heparin... 

Many drugs, especially quinidine and heparin, induce antibodies leading to thrombocytopenia. In most cases the antibodies are drug-dependent however, there are many examples in which the antibodies are autoimmune in nature [42], even for drugs, such as quinidine that are classically associated with drug-dependent antibodies [43], Gold therapy, in particular, is associated with autoimmune-thrombocytopenia [44],... 

Drugs that inhibit platelet function (e.g., aspirin) or produce thrombocytopenia increase the risk of bleeding when heparin is administered. Oral anticoagulants and heparin produce synergistic effects. Many basic drugs precipitate in the presence of the highly acidic heparin (e.g., antihistamines, quinidine, quinine, phenothiazines, tetracycline, gentamicin, neomycin). 

The use of vacutainer tubes and heparin was shown to alter the determination of protein binding. Heparin was shown to decrease the plasma binding of certain drugs including phenytoin, propranolol, lidocaine, diazepam, quinidine, and verapamil. This is also an in vitro artifact attributable to continued ex vivo activity of the lipoprotein lipase enzyme and accumulation of fatty acids in the blood collection tube. 

Clinically important, potentially hazardous interactions with amiodarone, clarithromycin, clopidogrel, desirudin, dextran, fondaparinux, gpiib/iiia receptor antagonists, heparin, quinidine, rifampin, St John s wort, sulfinpyrazone, thrombolytic agents, tidopidine, verapamil, vitamin k antagonists... 

The drug most commonly used in clinical practice that can produce immune thrombocytopenic purpura is heparin. Other examples are sulfonamides, thiazide diuretics, chlorpropamide, quinidine, and gold. These types of immune thrombocytopenic purpura are reversed when the drug is withdrawn. Molecular mechanisms for the formation of specific drug-dependent antibodies appear to be very similar. The glycoproteins on the platelet surface interact with the drugs to form neo-epitopes. Subsequent... 

A reduction in the labeling yield of RBC has been reported for heparin, tin-over-load, aluminum, prazocin, methyldopa, hydralazine, digoxin, quinidine, jff-adrenergic blockers, (e.g., propanolol), calcium channel blockers (e.g., verapamil), nitrates (e.g., nitroglycerin), doxorubicin, iodinated contrast agents, and Teflon tubing (catheter) (Hladik et al. 1987). 

Kessler KM, Leech RC, Spann IF, Blood collection techniques, heparin and quinidine protein binding, Clin Pharmacol Ther (1979) 25,204-10. 

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