Quercetin-7- O-glucuronide

Psoraleae fructus derivatives Bavachinin Isobavachalcone Punicagranatum extracts Qingxin kaiqiao formula Quercetin- 3 -O -glucuronide Radix morinda officinalis... 

Ho L, Ferruzzi MG, Janie EM, Wang J, Gong B, Chen TY et al (2013) Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer s disease. FASEB J 27 769-781... 

Quercetin, a flavonol, and corresponding quercetin-3-O-glucoside, quercetin-3-0-galactoside, quercetin-3-0-arabinoside, quercetin-3-O-glucuronide, and free quercetin are found in amounts of some milligrams to more than 300 mg kg (e.g., [56]). 

Figure 7.15 The isoflavone daidzein is found in soyabeans along with its 7-O-glucoside and malonyDglucoside. Genistein and its 7-O-glucoside and 7-0-(6"-malonyl)glucoside are also present. French beans contain quercetin-3-O-glucuronide in high amounts while caffeoyl-l-malic acid is present in pods of Vida faba.

Day et al. [2001] detected >20 species of metabolites, including quercetin 3-O-p-D-glucuronide (Q3GA), quercetin 3 -0-(3-D-glucuronide (Q3 GA), quercetin... 

Moon JH, Tsushida T, Nakahara K, Terao J. 2001. Identification of quercetin 3-O-beta-D-glucuronide as an antioxidative metabolite in rat plasma after oral administration of quercetin. Free Radio Biol Med 30 1274-1285. 

Bouktaib M, Atmani A, Rolando C (2002) Regio- and stereoselective synthesis of the major metabolite of quercetin, quercetin-3-O-P-d-glucuronide. Tetrahedron Lett 43 6263-6266... 

Kaempferol, kaempferol-3-O-P-D-galactopyranoside kaempferol-3-O-P-D-rutinoside (nicotiflorin), quercetin, quercetin-3-0-P-D-glucuronide methyl ester, quercetin-3-O-P-D-glucopyranoside (isoquercitrin), quercetin-3-O-P-D-galactopyranoside (hyperoside)... 

Terao J, Yamaguchi S, Shirai M, Miyoshi M, Moon JH, Oshima S, et al. Protection by quercetin and quercetin 3-O-beta-D-glucuronide of peroxynitrite-induced antioxidant consumption in human plasma low-density lipoprotein. Free Radic Res 2001 35 925-931. 

Shirai M, Moon JH, Tsushida T, Terao J. Inhibitory effect of a quercetin metabolite, quercetin 3-O-beta-D-glucuronide, on lipid peroxidation in hposomal membranes. J Agric Food Chem 2001 49 5602-5608. 

O Leary, K.A., Day, A.J., Needs, P.W., Mellon, F.A., O Brien, N.M., and Williamson, G., Metabolism of quercetin-7- and quercetin-3-glucuronides by an in vitro hepatic model the role of human (3-glucuronidase, sulfotransferase, catechol-0-methyltransferase and multi-resistant protein 2 (MRP2) in flavonoid metabolism, Biochem. Pharmacol, 65, 479, 2003. 

Figure 3 Structures of (A) hypericin (B) pseudohypericin (C) hyperforin (D) flavo-noids (R=H quercetin R=a-L-rhamnosyl quercitrine R=P-D-glucosyl isoquerci-trine R=P-D-galactosyl hyperoside R=P-D-rutinosyl rutin R=P-o-glucuronide miquelianin) and (E) procyandin B2.

Sesink, A.L., O Leary, K.A., and Hollman, P.C., Quercetin glucuronides but not glucosides are present in human plasma after consumption of quercetin-3-glucoside or quercetin-4 -glucoside, J. Nutr, 131, 1938, 2001. 

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