O-Glucuronidation

Figure 18.2 Representative receiver operator curves to demonstrate the leave n out validation of K-PLS classification models (metabolite formed or not formed) derived with approximately 300 molecules and over 60 descriptors. The diagonal line represents random. The horizontal axis represents the percentage of false positives and the vertical axis the percentage of false negatives in each case. a. Al-dealkylation. b. O-dealkylation. c. Aromatic hydroxylation. d. Aliphatic hydroxylation. e. O-glucuronidation. f. O-sulfation. Data generated in collaboration with Dr. Mark Embrechts (Rensselaer Polytechnic Institute).

Atomoxetine is excreted primarily as 4-hydroxyatomoxetine-O-glucuronide, mainly in the urine (greater than 80%) and to a lesser extent in the feces (less than 17%). 

Figure 3 Structures of (A) hypericin (B) pseudohypericin (C) hyperforin (D) flavo-noids (R=H quercetin R=a-L-rhamnosyl quercitrine R=P-D-glucosyl isoquerci-trine R=P-D-galactosyl hyperoside R=P-D-rutinosyl rutin R=P-o-glucuronide miquelianin) and (E) procyandin B2.

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