3-O-Glucuronide

Zamora-Ros et al [2006] carried out the first work that assessed the bioavailability of resveratrol (provided by different wines) in a regular intervention during 28 day. The analyses were performed by LC-MS/MS. In the first study, 10 healthy males were recruited to consume 300 mL/day of sparkling wine (1.19 mg resveratrol/1). After 28 day of supplementation, urinary trans-and m-resveratrol-3-O-glucuronides were 75 and 38 nmol/g creatinine, respectively. In the second study, 10 healthy females were selected to consume 200 mL of white wine (1.99 mg resveratrol/L) or 200 mL of red wine (12.8 mg resveratrol/L) in a crossover clinical trial. Likewise after 28 days only resveratrol metabolites were detected in morning urine, trans- (205 and 473 nmol/g creatinine) and ra-resveratrol-3-O-glucuronidcs (58 and 140 nmol/g creatinine) were found after white and red wine intake, respectively. Those studies showed that urinary excretion was dose dependent. Furthermore, slight amounts of resveratrol metabolites were also detected at baseline periods. No free resveratrol or piceid were detected in any of the studies. 

Table 7 Kinetics of Buprenorphine and Morphine-3-O-glucuronidation in UGT2B7 Variants...

Vesicular uptake studies are performed using the rapid filtration technique as reported by Chu et al. 1997. The transport medium contained the radiolabeled substrate (e.g. 3H-ethinylestradiol-3-0-sulfate or -3 -O-glucuronide, 3 H-estradiol-17(>-l)-glucuronide,... 

Psoraleae fructus derivatives Bavachinin Isobavachalcone Punicagranatum extracts Qingxin kaiqiao formula Quercetin- 3 -O -glucuronide Radix morinda officinalis... 

Ho L, Ferruzzi MG, Janie EM, Wang J, Gong B, Chen TY et al (2013) Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer s disease. FASEB J 27 769-781... 

In any event, the studies suggested that a hidden metabolite may be generated in the intestine idien BP-3-O-glucuronide is hydrolyzed by the microflora. 

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