Quassinoids from Ailanthus altissima

Only nine quassinoids possessing the C19 basic skeleton were isolated until 1985 samaderins B (11), C (12), D (13), an 3,4-dihydrosamaderin B (14) from the stem and leaves of Samadera indica, cedronin (15) and cedronolin (16) isolated from the fruits of Simaba cedron, eurycomalactone (17) and 5,6-dehydroeurycomalactone (18) from Eurycoma longifolia Jack, and shinjulactone B (19) isolated from Ailanthus altissima Swingle [1],... 

Ailantinol G (43) a quassinoid isolated from Ailanthus altissima was evaluated for its antitumor effects promotion against Epstein-Barr virus early antigen activation introduced by 12-0-tetradecanoylphorbol-13-acetate in Raji cells [25],... 

Forty-five quassinoids isolated from the three Simaroubaceous plants, Brucea javanica, Brucea antidysenterica and Picrasma ailanthoides, and fourteen isolated from Ailanthus altissima were tested for Okano et al. [106-108] for their inhibitory activities using a short-term in vitro assay of the EBV-EA activation induced by TP A in Raji cells. 

Kubota K, Fukamiya N, Hamada T, Okano M, Tagahara K, Lee KH (1996) Two new quassinoids, ailantinols A and B, and related compounds from Ailanthus altissima. J Nat Prod 59 683-686... 

IsHiBASHi, M., T. Murae, H. Hirota, T. Tsuyuki, T. Takahashi, A. Itai, and Y. Iitaka Shinjulactone C, a New Quassinoid with a la,12a 5a,13a-Dicyclo-9p /f-Picrasane Skeleton from Ailanthus Altissima Swingle. Tetrahedron Lett. 1205 (1982). 

Eighteen quassinoids glycosides and nine known quassinoids isolated from Brucea javanica, Brucea cmtidysenterica and Ailanthus altissima were tested for inhibitory activity against HIV replication in H9 lymphocytic cells [103],... 

Amarolide (267) is one of the representative quassinoid, and was first isolated from Ailanthus glcmdulosa [127] and A. altissima [128] being its structure established as (267). 

Dihydroailanthone (26) has been found as a minor quassinoid in the bark of Ailanthus glandulosa (=A. altissima) (8). The same structure was assigned to shinjulactone A isolated from the Japanese A, altissima (65). 

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