Pyridoxine Magnesium

These studies indicate an intimate relation between the magnesium level of the diet and the pyridoxine requirement. It is suggested (A6) that, insofar as growth and urinary excretion of citrates, oxalates, and xanthurenic acid are concerned, high levels of magnesium appear to have a sparing effect on very low dietary levels of pyridoxine. 

For the authors (PIO) the simplest explanation of the data on tryptophan metabolism in these 3 patients would be as follows in scleroderma (acrosclerosis) there was an abnormal urinary excretion of kynurenine and its metabolites after oral ingestion of tryptophan. The administration of pyridoxine or pyridoxine plus nicotinamide partially corrected the metabolic abnormality. The efficacy of pyridoxine plus Na2EDTA could be explained on the basis of a decrease in tissue calcium and zinc (and possibly other cations), enabling the metal ions, normally functioning with pyridoxal phosphate, as magnesium ions, to be utilized more advantageously. 

Essential fatty acids (omega-3 fatty acids), various products and dosages Pyridoxine up to 100 mg/day Vitamin E up to 800 lU/day Calcium carbonate up to 2000 mg/day Magnesium up to 400 mg/day Second- and Third-Line Treatment Approaches Dysmenorrhea... 

Magnesium is involved with many neuromuscular activities and cellular pathways that may affect PMS. Low intracellular magnesium levels have been reported in women with PMS compared with controls. It has been suggested that PMS may be related to an increased serum calcium-to-magnesium ratio. Daily or luteal magnesium supplementation of 200-360 mg/day was reported to be minimally helpful in reducing premenstrual fluid retention in women with PMS. A daily supplementation of 200 mg magnesium and 50 mg pyridoxine was found to reduce anxiety-related premenstrual symptoms in women with PMS compared with placebo. ... 

Minerals and vitamins are usually found in BSG [27]. The mineral elements include aluminum, barium, calcium, chromium, cobalt, copper, iron, magnesium, manganese, phosphorus, potassium, selenium, silicon, sodium, strontium, sulfur, and zinc, typically all in concentrations lower than 0.5%, except for silicon that is the major mineral present. The vitamins include biotin, choline, folic acid, niacin, pantothenic acid, riboflavin, thiamine, and pyridoxine. Although, many of the vitamins can be destroyed during the hydrolysis... 

Ingredients Calcium Carbonate, Microcrystalline Cellulose, Magnesium Oxide, Ferrous Fumarate, Ascorbic Acid, Maltodextrin, Gelatin, dl-Alpha-Tocopheryl Acetate, Dicalcium Phosphate Less than 2% of Beta-Carotene, Biotin, Cholecalciferol, Croscarmellose Sodium, Cupric Oxide, Cyanocobalamin, D-Calcium Pantothenate, FD C Red 40 Dye, FD C Red 40 Lake, FD C Yellow 6 Lake, Folic Acid, Hydroxypropyl Methylcellulose, Niacinamide, Polyethylene Glycol, Polysorbate 80, Potassium Iodide, Pyridoxine Flydrochloride, Riboflavin, Silicon Dioxide, Soybean Oil, Starch, Stearic Acid, Thiamine Mononitrate, Titanium Dioxide (color), Vitamin A Acetate, Zinc Oxide... 

Linoleic acid Magnesium phosphate tribasic Manganese citrate (ous) Manganese sulfate (ous) Nicotinic acid Pyridoxine HCI Retinol Retinyl acetate Riboflavin-5 -phosphate sodium Thiamine HCI... 

Yiiksel, N Turkmen, B Kurdoglu, A Ba aran, B Erkin, J Baykara, Fabad T. Lubricant efficiency of magnesium stearate in direct compressible powder mixtures comprising Cellactose 80 and pyridoxine hydrochloride. J Pharm Sci, 2007, 32, 173-183. 

In cats, pyridoxine deficiency is associated with the formation of calcium oxalate calculi in the kidneys. The magnesium and pyridoxine levels in the diet are related. Diets low in magnesium are responsible for increased incidence and severity of the oxalate lithiasis in the kidney, and the effect of the low-magnesium diet is counteracted by the administration of pyridoxine. These observations made in animals may have some relevance to the development of lithiasis in humans. Patients with recurring calcium oxalate stones in the kidney secrete more xanthurenic and pyridoxic acid than normal individuals, suggesting that lithiasis may result from deficient pyridoxine metabolism, possibly due to accelerated breakdown of the coenzyme. If other signs of pyridoxine deficiency develop, one must assume that the accelerated breakdown occurs only in a few organs, probably only in the kidneys. 

Kinases catalyzing the phosphorylation of pyridox-ine, pyridoxamine, and pyridoxal have been found in microorganisms and in mammalian tissues. The kinases require zinc and magnesium, and ATP acts as phosphate donor. The affinity for the substrate varies depending on the source pyridoxine and pyridoxamine are the preferred substrates with yeast enzyme, but the mammalian enzyme has a greater affinity for pyridoxal. 

The dietary factors studied in detail have been amount of calories ( overweight or not), refining of foods, fruits and vegetables, fats, proteins, carbohydrates, cholesterol, vitamins A, D (cod liver oil), E, and B (especially niacin and pyridoxine), choline, cystine, methionine, and minerals (copper, magnesium, sodium, potassium). In the following discussions the disease for which the best documentation was found is usually described first. 

Important may also be the fact that pyridoxine raises the magnesium level in blood (Buscaino and Balbi, 1957). 

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