Psychotomimetic

Strike can t believe Strike can actually quote Strike s own book. That is so freaky )]. Most of these things will make amphetamines that are much more potent than X. It is also possible to play around with some of the little side groups on these to eventually make X or some other interesting psychotomimetics. With few exceptions these precursors are all substituted allylbenzenes just like safrole. They are all found in the same kind of legal oils and sold in the same kinds of places as sassafras. Finally, these precursors are turned into their own respective amphetamines using the exact same conversion recipes used for safrole. 

For many years it was believed that the brain mechanisms underlying the effects of psychedelic hallucinogens and dissociative anesthetics were separate and distinct. Indeed, there has been considerable debate about which represents the best drag model of schizophrenia. However, recent data show that the two classes of psychotomimetic drags share a common final pathway involving an increase in the release of the excitatory neurotransmitter glutamate. 

Psychotomimetic drags can be defined as chemical agents that reliably and dose-dependently induce a psychosis, often including hallucinations and delusions in normal individuals. Implicit in this term is a mimicking of naturally occulting psychosis. 

Psychotomimetic Drugs. Figure 2 Chemical structures of the dissociative anesthetics phencyclidine (PCP) and ketamine. Both are arylcycloalkylamine derivatives that are open channel blockers of the NMDA channel. 

Psychedelic Hallucinogen Psycho Energizers Psychomotor Stimulant Diugs Psychostimulants Psychotogenic Psychotomimetic Drugs PT... 

Delta Dysphoria, psychotomimetic effects (eg, hallucinations), respiratory and vasomotor stimulations caused by drugs with antagonist activity... 

Although the exact mechanisms of action of LSD and tryptamine-related compounds are incompletely understood (Freedman 1987), there is convincing evidence relating the psychotomimetic effects of these substances to serotonergic transmission in the brain (Davis 1987 Freedman 1987 McCall 1986 Nichols 2004). An antagonism of 5-HT in the rat brain is sufficient to cause a fourfold decrease in the threshold dose ofLSD (Appel and Freedman 1964). 

Shulgin AT Hallucinogens, in Burger s Medicinal Chemistry, 4th Edition, Part 3. Edited by Wolff ME. New York, Wiley, 1981, pp 1109-1137 Shulgin AT Psychotomimetic drugs structure-activity relationships, in Handbook of Psychopharmacology, Vol 11. Edited by Iversen LD, Iversen SD, Snyder SH. New York, Plenum, 1978, pp 243-336... 

MDA had unique psychoactive properties that were different from hallucinogens such as LSD or mescaline. While MDA in high doses appears to be hallucinogenic or psychotomimetic, it seems not to have been used for this effect, but rather for its effects on mood production of a sense of decreased anxiety and enhanced self-awareness. Even early reports described the desire of MDA users to be with and talk to other people (Jackson and Reed 1970). MDA is also the only substituted amphetamine that received serious clinical study as an adjunct to psychotherapy (Yensen et al. 1976). 

Shulgin, A.T. Psychotomimetic drugs Structure-activity relationships. In Iversen, L.L. Iversen, S.D. and Snyder, S.H., eds. Handbook of Psychopharmacology. Vol. 11. New York Plenum, 1978. pp. 243-333. Shulgin, A.T., and Carter, MF. Centrally active phenethylamines. 

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