Psoriasis, risk factor

Cyclosporine and tacrolimus are calcineurin inhibitors that are administered as part of immunosuppressive regimens in kidney, liver, heart, lung, and bone marrow transplant recipients. In addition, they are used in autoimmune disorders such as psoriasis and multiple sclerosis. The pathophysiologic mechanism for ARF is renal vascular vasoconstriction.41 It often occurs within the first 6 to 12 months of treatment, and can be reversible with dose reduction or drug discontinuation. Risk factors include high dose, elevated trough blood concentrations, increased age, and concomitant therapy with other nephrotoxic drugs.41 Cyclosporine and tacrolimus are extensively metabolized by... 

What risk factors does he have for psoriasis ... 

Stiller MJ, Pak GH, Kenny C, Jondreau L, Davis I, Wachsman S, Shupack JL. Elevation of fasting serum lipids in patients treated with low-dose cyclosporine for severe plaque-type psoriasis. An assessment of clinical significance when viewed as a risk factor for cardiovascular disease. J Am Acad Dermatol 1992 27(3) 434-8. 

Possible risk factors include trauma, unusual physical exercise, surgery, severe systemic illness, severe dieting, dietary excess, alcohol, drugs, status epilepticus, psoriasis, renal failure, lead intoxication, Down s syndrome, high purine diet, cytolytic therapy, myeloproliferative and lymphoproliferative disorders. Mr KT has several risk factors which increase his chances of developing gout ... 

UVA combined with oral methoxsalen is a photochemotherapeu-tic approach to treatment of psoriasis. Although burdensome, photochemotherapy is an important treatment consideration for patients with moderate to severe psoriasis, when time needed to treat and risk factors are balanced with potential benefit. 

Historically, the long-term management of psoriasis has been complicated by a variety of treatment-related factors, including inconsistent efficacy over time, the risk of significant cumulative toxicides, and patient dissatisfaction... 

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