Psoriasis prevention

Non-medicated moisturizers. Maintaining adequate skin moisture helps to control the scaling associated with psoriasis. Emollients restore skin pliability, reduce skin shedding, reduce pruritus, and help prevent painful cracking and bleeding.2 Non-medicated moisturizers may be liberally applied several times daily to help prevent skin dryness. Fragrance-free products should be selected when available. 

Etanercept is a fully human dimeric fusion protein composed of human TNF-a p75 receptor fused to the Fc portion of human IgG 1.41 It acts as a tumor necrosis factor-a (TNF-a) inhibitor by binding to and inactivating TNF-a, thus preventing interactions with its cell surface receptors.41 This agent is useful for chronic moderate to severe plaque psoriasis and for psoriatic... 

Mechanism of Action An immunologic agent that interferes with the activation of T-lymphocytes by binding to the lymphocyte antigen, thus reducing the number of circulating T-lymphocytes. Therapeutic Effect Prevents T cells from becoming overactive, which may help reduce symptoms of chronic plaque psoriasis. Pharmacokinetics Half-life 270 hr... 

Mechanism of Action A synthetic vitamin Dj analog that regulates skin cell (kerat-inocyte) production and development. Therapeutic Effect Preventing abnormal growth and production of psoriasis (abnormal kerafinocyte growth). Pharmacokinetics Minimal absorption through intact skin. Metabolized in liver. 

Unlabeled Uses Prevention of organ rejection in patients receiving allogeneic bone marrow, heart, pancreas, pancreatic island cell, or small-bowel transplant, treatment of autoimmune disease, severe recalcitrant psoriasis... 

It is used to prevent graft rejection after kidney, liver, heart, lung, pancreas transplant or bone marrow transplantation and psoriasis not responding to conventional therapy. 

G. Other applications Simulect may have application in the prevention of liver allograft rejection and in the treatment of psoriasis. 

Cyclosporine is used to prevent organ rejection after tissue transplantation. It is also used for rheumatoid arthritis, psoriasis and dry eyes (keratoconjunctivitis sicca). For... 

Daily administration of colchicine is useful for the prevention of attacks of familial Mediterranean fever (familial paroxysmal polyserositis) and for prevention and treatment of amyloidosis in such patients. Colchicine appears to benefit patients with primary biliary cirrhosis in terms of improvement of liver function tests and perhaps of survival. Colchicine also has been employed to treat a variety of skin disorders, including psoriasis and Behcet s syndrome. 

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