Psilocybin

A number of mushrooms, liberty cap (psilocybe), psilocybin, fly agaric, Amantia muscaria and the peyote cactus contain hallucinogenic agents. They are usually eaten raw but can be dried out and stored or cooked into food or made into a tea and drunk. The effects are highly variable and whereas 20-30 liberty caps would be required to give a full dose, just one fly agaric mushroom would produce similar actions. Some recent local surveys in the UK have found between 12% and 15% of 16-year-olds claiming to have used these at least once. 

Interest in the psychotropic features of the mushroom substance, psilocybins, led to an exploration of the chemistry of 4-hydroxyindo1e (10). The availability of this substance provided a suitable starting point for the synthesis of pindolol (12), a p-adrenergic... 

DMT is perhaps the most powerful hallucinogen known to man. It is related to LSD and psilocybin. There are no drug tests that would show DMT usage. None of the basic NIDA-5 drug tests or any extended drug test will show a result for DMT. DMT is naturally formed in the body and has been found in abnormal levels in the body fluids of persons suffering from schizophrenia. DMT is almost never sold through dealers, rarely synthesized, and seldom used. It is, however, easily extracted from common plant materials and has been used in various forms for hundreds of years (timeline.) DMT is not a... 

Psilocybin An indolylamine hallucinogen found in a number of mushrooms of the... 

Davis, M., and Walters, J. K. (1977) Psilocybin Biphasic dose-response effects on the acoustic startle reflex in the rat. Pharmacol. Biochem. Behav., 6 427-431. 

The natural prototype for the phenylalkylamines is mescaline (Structure 1), isolated from the peyote cactus (Lophophora williamsii) by Heffter in 1896 (100) and subsequently obtained synthetically by Spath in 1919 (218). Used for many centuries in the form of peyote by Indians in Mexico and the American Southwest (3), it is often referred to as one of the classic hallucinogens, along with psilocybin, psilocin, and LSD. Little structure-activity work was directed toward mescaline or its congeners until 1955, when Peretz et al. (174) reported that a-methyl mescaline (TMA) (8), which represented a hybrid of the structure... 

Baker, R. W., Chothia, C., Pauling, P., and Weber, FI. P. (1973) Molecular structures of hallucinogenic substances Lysergic acid diethylamide, psilocybin, and 2,4,5-trimethoxyam-phetamine. Mol. Pharmacol., 9 23-32. 

Weidmann, H., and Cerletti, A. (1960) Studies on psilocybin and related compounds. Helv. Physiol. Acta, 18 174-182. 

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