Pseudo poly applications

Applications of Ester-Based "Pseudo" 12.6 Urethane-Based "Pseudo" Poly(Amino Acids) 213... 

Applications Poly(Amides) as "Pseudo" Poly(Amino Acids)... 

Abstract A review is presented of the main types of bioresorbable or bioabsorbable materials used in medical applications such as drug delivery. Groups discussed include aliphatic polyesters, polyanhydrides, poly(ortho esters) (POE), polyphosphazenes, poly(amino acids) and pseudo poly(amino acids), polyalkylcyanoacrylates, poly(propylene fumarate) (PPF), poloxamers, poly(p-dioxanone) (PPDO) and polyvinyl alcohol (PVA). 

The development of pseudo-poly(amino acids) represents an attempt to circumvent some of the unfavorable material properties of conventional poly (amino acids), and to increase the range of amino acid derived polymers that can be considered for industrial and/or medical applications. In pseudo-poly(amino acids), naturally... 

Pseudo-poly(amino acids) were first described in 1984 (Kohn, 1984) and have since been evaluated for use in several medical applications (Kohn, 1987 Yu-Kwon, 1989 Zhou, 1990 Kohn, 1993 Mao, 1993). Although a range of different pseudo-poly(amino acids) has been prepared, detailed studies of the physical properties, biological properties, and possible applications of these polymers have so far been conducted only for a select group of new tyrosine- derived polycarbonates, polyiminocarbonates, and polyarylates. This review will encompass the work to date on these specific materials. 

The design of tyrosine-derived pseudo-poly(amino acids) has circumvented many of the traditional limitations of conventional poly (amino acids), giwng rise to novel and useful biomaterials covering a wide range of potential biomedical applications. 

Kohn, J. (1993) Design, syntliesis, and possible applications of pseudo-poly(amino acids). Trends Polym. S ., 1(7),206-21X... 

Pulapura, S. and Kohn, j. (1992) XyTOsine derived polycarbonates Backbone modified, pseudo -poly(amino acids) designed for biomedical applications. Biopolymers, 32, 411-417. 

Pulapura and coworkers replaced bisphenol A with derivatives of tyrosine dipeptide resulting in a iminocarbonate-amide copolymer. The iminocarbonate bond was formed between the phenolic hydroxyl group at the tyrosine side chains. These iminocarbonate-amide copolymers can be regarded as pseudo-poly(amino acids) and are being evaluated in biomedical applications. 

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