Prous

T. Clark, Quantum chemoinformatics an oxymoron (Part 2), in Rational Approaches to Drug Design, H.-D. Holtje, W. Sippl (Eds.), Prous Science, Barcelona, 2001, pp. 29-40. 

E. San2,J. Giraldo, andE. lsl. 2ia2LU., QSAR and Molecular Modeling Concepts, Computational Methods and Biological Applications,]. R. Prous Science Pubhshers,... 

A. Keerkenaar, in R. A. Fromtiing, ed.. Recent Trends in the Discovey, Development and Evaluation of Antifungal Agents, J. R. Prouse, Science PubHshers, Barcelona, Spain, 1987, p. 523. 

The following chemical databases are available for searching in MACCS-II. ChemicalDirectoy Database contains a combined catalogue of 66 commercial suppHers of more than 77,000 organic chemicals. AL4.CCS-II Drug Data eport based on the Prous Dmg Data Report, includes 39,000 compounds with information on therapeutic indication, biological action, phase of development, related patents, and Hterature references. MUSE Database the tutorial database for MACCS-II, contains over 100 compounds. 

Prous, J.R., editor. Drugs of the Future, Provenza 385-87, Barcelona-13, Spain. 

Silvetre, J. S., and Prous, J. (2005). Research on adverse drug events Muscarinic m3 receptor binding affinity could predict the risk of antipsycho tics to induce type 2 diabetes. Meth. Find. Exp. Clin. Pharmacol. 27 289-304. 

Pirogov SV, Mel nikova SF, Tselinskii IV, Romanova TV, Spiridonova NP, Betin VL, Postnikov AB, Kots AY, Khropov YV, GavrUova SA, Grafov MA, Medvedeva NA, Pyatakova NV, Severina IS, Bulargina TV (2004) RU Patent 2240321 Sankaranarayanan A (2003) WO Patent 2003053439 Prous JR (1999) Annu Drug Data Rep 21 787... 

Investigation of calculated hydrogen bond parameters for QSAR. In Computational Tools and Biological Applications, Sanz, F., Giraldo, J., Manaut, F. (eds.), Prous, Barcelona, 1995, pp. 117-119. 

V. A., Zefirov, N. S. Extended parameterization of Rekker s/system for drug lipophilidty calculation. In Proc. 10th Eur. Symp. on Structure-Activity Relationships. Prous, Barcelona, 1995, abstr. B263. 

Prous, A., Malta, I.M. Santana do Riacho, Tomo I. Arquivos do Museu de Historia Natural 12, 384 (1991)... 

E. Tomlinson, in QSAR in Design of Bioactive Compounds (M. Kuchar, ed.), Prous, Barcelona, 1984, p. 219. 

CSline. CSline [84] provides information on well-designed and well-executed clinical trials of drugs currently under study or in use in humans. This information includes study objectives, design, population, intervention groups, withdrawals, adverse reactions, endpoints and results, conclusions, and references. The CSline database covers more than 500 drugs currently on the market or in development. Pharmacological data from more than 2000 journal articles, congresses, and books are added each year. The product is commercially available on CD-ROM from Prous Science and is updated every 2 months. 

CSline, [Internet]. URL http //www.prous.com/pro-duct/electron/csline.html, accessed 7-30-2000. 

Helmig R., Class H., et al. Architecture of the modular program system MUFTE-UG for simulating multiphase flow and transport processes in heterogeneous prous media. 1998 MathematischeGeologie2 123-131. 

P. Braquet, Ginkgolides Chemistry, Biology, Pharmacology and Clinical Perspectives, ed. P. Braquet (J.R. Prous Science Publishers, Barcelona, 1988). 

Kier LB, Hall LH (1992) In Biaggi A (ed) Design of bioactive compounds, a telesymposium. Prous Publishers... 

Kola, I. and Rafferty, M., New technologies that may impact drug discovery in the 5-10 year timeframe workshop, 2002 Biomed. Expo Ann Arbor Michigan, Data derived from Prous Science, Drug News Prospect, 2002. 

MDDR and ACD are available from MDL Information Systems, http //www.mdli.com/products/finders/ database.finder/ MDDR is developed in cooperation with Prous Science Publishers, 2004,... 

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