Protooncogenes

Izumo, S., Nadal, G.B., Mahdavi, V. (1988). Protooncogene induction and reprogramming of cardiac gene expression produced by pressure overload. Proc. Natl. Acad. Sci. USA 85, 339-343. 

Nagata H, Worobec AS, Oh CK, et al Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder. Proc Natl Acad Sci USA 1995 92 10560-10564. 

Cytoplasmic serine/threonine protein kinases catalyze the transfer of phosphate groups to serine and threonine residues of target proteins. Serine/threonine kinases have been recognized as the products of protooncogenes (e.g., c-mos, c-raj) or as kinases intimately involved with the regulation of serine/threonine kinase activity by cAMP. Some of these kinases specifically phosphorylate cellular structural proteins, such as histone, laminins, etc. Others phosphorylate still more kinases, resulting in either the activation or deactivation of downstream protein kinases. Specific examples in which serine/threonine kinases elicit specific cellular responses are discussed in this chapter. 

Kanki, J. P, and Donoghue, D. J. (1991). Progression from meiosis I to meiosis II in Xenopus oocytes requires de novo translation of the mos" protooncogene. Proc. Natl. Acad. Sci. USASS 5794-5798. 

Mutter, G. L., and Wolgemuth, D. J. (1987). Distinct developmental patterns of c-mos protooncogene expression in female and male mouse germ cells. Proc. Nad. Acad. Sci. USA 84 5301-5305. 

Paules, R. S., Buccione, R., Moschel, R. C., Vande Woude, G. F., and Eppig, J. J. (1989). Mouse Mos protooncogene product is present and functions during oogenesis. Proc. Natl. Acad. Sci. USA 86 5395-5399. 

Giebel, L. B., and Spritz, R. A. (1991). Mutation of the KIT (mast/stem cell growth factor receptor) protooncogene in human piebaldism. Proc. Natl. Acad. Sci. USA 88 8696-8699. 

Several cytoplasmic proteins capable of inducing T-cell growth (i.e. several cellular protooncogenes, including C-fos and C-myc). 

PAZ-ARES, J., GHOSAL, D., WIENAND, U., PETERSON, P.A., SAEDLER, H., The regulatory cl locus of Zea mays encodes a protein with homology to myb protooncogene products and with structural similarities to transcriptional activators, EMBOJ., 1987, 6, 3553-3558. 

Li, J. et al., Tumor promoter arsenite stimulates histone H3 phosphoacetylation of protooncogenes c-fos and c-jun chromatin in human diploid fibroblasts, J. Biol. Chem., 278, 13183, 2003. 

Rong, S., and G. F. Vande Woude. 1994. Autocrine mechanism for met protooncogene tumorigenicity. Cold Spring Harb Symp Quant Biol 59 629-36. 

F. Trump, and C. C. Harris. 1991. Human bronchial epithelial cells transformed by the c-raf-1 and c-myc protooncogenes induce multidifferentiated carcinomas in nude mice A model for lung carcinogenesis. Cancer Res 51 3793-3801. 

Nelson SM, Ferguson LR, Denny WA (2005) Demonstration by real time polymerase chain reaction that cellular DNA alkylation by novel aminoindoline compounds affects expression of the protooncogene c-myc. Chem Res Toxicol 18(2) 239-248... 

Luo L-G, Jackson IMD. 1999. Advantage of double labeled in situ hybridization for detecting the effects of glucocorticoids on the mRNAs of protooncogenes and neural peptides TRH in cultured hypothalamic neurons. Brain Res Prot 4 201-208. 

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