Proteins polymer-protein conjugates

This will allow us to rapidly converge upon a highly optimized polymer-protein conjugate based on NIPA hydrogels. (Adapted from Lyon, 2000)... 

Polymer-based delivery systems (Fig. 11.1) include polymer-protein conjugates, polymer-drug conjugates, micelles consisting of polymeric surfactants, and complexes of cationic polymers and DNA (polyplexes).26... 

Since the early 1990s, a number of polymer-protein conjugates have been approved for medical use by the Food and Drug Administration (FDA), and clinical trials of the polymer conjugates of anticancer drugs have seen promising results, all of which quickly changed the conception of polymer-based therapeutics from a scientific curiosity to a clinical reality. 

Polymer-protein conjugates (see Fig. 11.1 a). The phenomenal advances in molecular cloning and monoclonal antibody technology have rendered... 

For this reason, although the first polymer-protein conjugates used clinically were streptokinase conjugated to dextran [8] and neocarzinostatins linked to succinic acid-co-maleic anhydride [5], from the 1980s onwards PEG became the polymer of choice, and all products that subsequently appeared on the market were based on this reagent. 

An interesting application of polymer protein conjugates has been reviewed by Alexander et al. [75,76]. By connecting stimulus responsive synthetic polymers to enzymes, the enzyme activity could be directed by varying temperature or by UV illumination, since this resulted in a change in hydro-dynamic volume of the polymers attached [77]. In general, the attachment of polymer chains proved to stabilize the enzymes. In case of the prote-... 

Table 1.1 Polymer-protein conjugates available commercially, or in clinical development...

Schilli, C. M. Mueller, A. H. E. Rizzardo, E. etal. RAFT Polymers Novel Precursors tor Polymer-Protein Conjugates, Matyjaszewski, K Ed. ACS Symposium Series Washington DC, 2003 Vol. 854 p. 603. 

Hybrid Polymeric Drugs Based on Polymer-Protein Conjugates... 

Gonzalez-Valdez J, Rito-Palomares M, Benavides J. Advances and trends in the design, analysis, and characterization of polymer-protein conjugates for PEGylaided bioprocesses. Anal Bioanal Chem. 2012 403 2225-35. 

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