Antibody technology, monoclonal

Biotech products based on recombinant DNA, gene expression or hybridoma/monoclonal antibody technologies. 

The advent of genetic engineering and monoclonal antibody technology underpinned the establishment of literally hundreds of start-up biopharmaceutical (biotechnology) companies in... 

During the 1980s, rapid developments in the areas of recombinant DNA technology and monoclonal antibody technology contributed to a greater depth of understanding of cytokine biology ... 

Monoclonal antibody technology entails isolation of such B-lymphocytes, with subsequent fusion of these cells with transformed (myeloma) cells. Many of the resultant hybrid cells retain immortal characteristics, while producing large quantities of the monospecific antibody. These hybridoma cells can be cultured long term to effectively produce an inexhaustible supply of the monoclonal antibody of choice. 

I would like to acknowledge Dr. Jack Dunne, who introduced me to monoclonal antibody technology and immunocytochemistry on whole-mounts and... 

The combination of the specificity of the antigen-antibody interaction with the exquisite sensitivity of fluorescence detection and quantitation yields one of the most widely applicable analytical tools in cell biology (1). Within the last decade, flow cytometry (FCM) has become an integral part of basic immunological research. Elaboration of this technology has been intensively stimulated by a rapidly growing sophistication in monoclonal antibody technology and vice versa (2). 

Progress in the field of drug targeting has been slow till thirty years ago. With the advent of the monoclonal antibody technology in the mid seventies of the last century as well as the development of liposomal devices as carriers did the drug targeting field expand and did the clinical application become a feasible aim. 

Antibody Resource, http //www.antibodyresource.com/educational.html Campbell, A.M. (1984). Monoclonal Antibody Technology. Elsevier, Amsterdam. 

Polymer-protein conjugates (see Fig. 11.1 a). The phenomenal advances in molecular cloning and monoclonal antibody technology have rendered... 

Krogsrud S, Lang KT. 1989. USA Army toxic and hazardous materials agency monoclonal antibody technology program [Abstract], Abstract Papers of the American Chemical Society 198 AGRO 58. 

Krogsrud S, Lang KT. 1990. Monoclonal antibody technology program. In Van Emon JM, Mumma RO, eds. Immunochemical methods for environmental analysis. American Chemical Society Symposium Series No. 442, 1987 National Meeting, Miami Beach, Florida. Washington, DC American Chemical Society, 21-26. 

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