Proteinase characteristics

B4. Barrett, A. J., and Starkey, P. M., The interaction of a2-macroglobulin with proteinases. Characteristics and specificity of the reaction, and a hypothesis concerning its molecular mechanism. Biochem. J. 133,709-724 (1973). 

Proteinase Characteristic Molecular weight Specific inhibitors from yeast Intracellular localization... 

Smyth, M. and FitzGerald, R.J. 1998. Relationship between some characteristics of WPC hydrolysates and the enzyme complement in commercially available proteinase preparations. Int. Dairy J. 8, 819-827. 

N8. North, M. J., The characteristics of cysteine proteinases of parasitic protozoa. Biol. Chem. Hoppe Seyler 373(7), 401 106 (1992). 

Encron rizolipasc. endogenous pyrogen > interleukin-1. ENDOPEPTIDASE INHIBITORS act at one or other of the endopeptidase enzymes that cleave the C-terminal residue from oligopeptides or proteins (thus are stricdy proteinases). They can be divided into classes on the basis of their functional characteristics. These classes are dealt with separately in terms of their alternate names, notable substrates and inhibitors. They often act along with ectopeptidases - the carboxypeptidases and amino-peptidases. Endopeptidase inhibitors contain members of the metalloproteinase and serine protease families. Some are important neuropeptidases - concerned with degradation of... 

A proteinase inhibitor characteristic of acute-phase inflammation, al-antichymo-trypsin (ACT) has been identified in SP and reported to be elevated in AD patients (283). The level of ACT depended on ApoE genotype and was the highest in e3/e3 homozygotes and correlated with cognitive impairment and duration of the disease. The e4 genotypes have shovm a lower level of ACT and no correlation with impairment or duration. One should keep in mind that the same ACT inhibits Aj3... 

Heparin has been used clinically for decades to prevent and treat thromboembolic disease and is isolated on an industrial scale from animal tissues, in particular pig intestinal mucosa. The conesponding physiological blood anticoagulant is presumably not heparin, but an HS species that is located on the surface of vascular endothelial cells. Both heparin and HS contain a specific pentasaccharide sequence that binds and activates the plasma proteinase inhibitor AT. This pentasaccharide sequence (4) is present only in a subfraction of heparin and HS preparations. It displays a characteristic structural feature, namely a 3-0-sulfated GlcN residue, that is only rarely seen in other portions of heparin/HS chains. 

Hartree, E.F. (1977). Spermatozoa, eggs, and proteinases. Biochem. Soc. Trans. 5 375-383. Hildebrandt, J.D., Codina, J., Tash, J., Kirchick, H.J., Lipschultz, L., Sekura, R.D., and Bimbaumer, L. (1985). The membrane-bound spermatozoal adenylyl cyclase does not share coupling characteristics with somatic cell adenylyl cyclases. Endocrinol. 776 1357- 1363. 

B. S. Baines and K. Brocklehurst. Isolation and characterization of the four major cysteine-proteinase components of the latex of Carica papaya L. Reactivity characteristics towards 2,2 -dipyridyl disulfide of the thiol groups of papain, chymopapains A and B, and papaya peptidase A. J. Protein Chem. 7 119 (1982). 

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