Supramolecular protein chemistry

Cation-n Interactions, p. 214 Crown Ethers, p. 326 Fluorescent Sensors, p. 572 lonophores, p. 760 Organic Zeolites, p. 996 Platonic and Archimedean Solids, p. 1100 Protein Supramolecular Chemistry, p. 1161 Simultaneous Binding of Cations and Neutral Molecules, p. 1295... 

Protein Supramolecular Chemistry, p. 1161 Solid-State Nuclear Magnetic Resonance Spectroscopy, p. 1307... 

Molecular-Level Machines, p. 931 O2 Uptake and Transport, Models of, p. 1023 Porphyrin Derivatives, Functional, p. 1139 Protein Supramolecular Chemistry, p. 1161 Vitamin Bj2 and Heme Models, p. 1569... 

Protein Supramolecular Chemistry, p. 1161 Rotaxanes and Pseudorotaxanes, p. 1194 Selectivity Thermodynamic and Kinetic, p. 1225 Self-Assembly Definition and Kinetic and Thermodynamic Considerations, p. 1248... 

Anion-Directed Assembly, p. 51 Enzymes Characteristics and Mechanisms, p. 554 Hydrogen Bonding, p. 658 Molecular Squares, Boxes, and Cubes, p. 909 Molecular-Level Machines, p. 931 Protein Supramolecular Chemistry, p. 1161 Racks, Ladders, and Grids, p. 1186 Self-Assembling Catenanes, p. 1240 Self-Assembly Definition and Kinetic and TTjermot/ynam-ic Considerations, p. 1248 Self-Assembly in Biochemistiy, p. 1257 The Template Effect, p. 1493... 

DNA is ideally suited as a structural material in supramolecular chemistry. It has sticky ends and simple rules of assembly, arbitrary sequences can be obtained, and there is a profusion of enzymes for modification. The molecule is stiff and stable and encodes information. Chapter 10 surveys its varied applications in nanobiotechnology. The emphasis of Chapter 11 is on DNA nanoensembles, condensed by polymer interactions and electrostatic forces for gene transfer. Chapter 12 focuses on proteins as building blocks for nanostructures. 

Sage, I.T., Champion, P.M. Small substrate recognition in heme proteins. In Suslick, K.S. (ed.) Comprehensive Supramolecular Chemistry. Pergamon, Oxford (1996)... 

Therapeutic gold complexes, 12 700-701 Therapeutic index, 18 252 Therapeutic pet foods, 10 849 Therapeutic products, from genetically engineered microbes, 12 480 Therapeutic proteins, 3 816 Therapeutics, supramolecular chemistry in, 24 56-57... 

In recent years, supramolecular chemistry has produced a number of systems which have been shown to be able to effectively catalyze a Diels-Alder reaction. Most systems selectively afforded only one diastereomer because of a pre-organized orientation of the reactants. These systems include cyclodextrines, of which applications in Diels-Alder chemistry have recently been reviewed89. Some other kinds of non-Lewis acid catalyzed Diels-Alder reactions, including catalysis by proteins and ultrasound, have been discussed by Pindur and colleagues90. 

The text has been substantially revised, many new examples incorporated and errors corrected. A substantial new chapter dealing with supramolecular chemistry has been incorporated. Once again, a deliberate decision was made to try to limit references to the secondary rather than the primary literature. Where structural data have been presented, the use of the files of the Cambridge Crystallographic Data Centre and the Brookhaven Protein Structure Data Base are gratefully acknowledged. 

We saw in Figure 1.2c that supramolecular chemistry is not just about solid state or solution host-guest chemistry but increasingly emphasises self-assembly and the construction of multi-nanometre scale devices and ultimately materials based on nanometre-scale components (a nanometre is 10 9 of a metre). Strict supramolecular self-assembly (Chapter 10) involves the spontaneous formation of a multi-component aggregate under thermodynamically controlled conditions based on information encoded within the individual building blocks (referred to as tectons ) themselves. The aggregate might comprise only one kind of molecule (as in the multiple copies of the same protein that comprise... 

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