Supramolecular protein chemistry enzyme complexes

In summary, the Ion Evaporation Model is experimentally well supported for small ions of the kind that one encounters in inorganic and organic chemistry. However, when the ions become very large, such as polymers, dendrimers or biological supramolecular complexes like proteins and enzymes, the Charged Residue Model (CRM) becomes much more plausible, see Section 1.2.10. Because many applications of ESMS in analytical organometallic and physical organic chemistry involve small ions it is desirable to consider the expected relative sensitivities for these analytes when detected with ESMS. 

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