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Protein Modification Screening Tool

Numerous modifications are in place at each lab regarding incubation conditions like substrate concentration, incubation time, cofactor use and concentration, protein concentration etc. These modifications depend on the purpose of the method, e.g. as a high through-put screen in early drug discovery or as a tool to characterize a development compound in vitro for regulatory files. Besides these modifications on the biological part of the assay, specific protocols on pipetting robots and conditions used for evaluation by LC-MS/MS also in combination with the instrumental equipment available are applied which are typically not published. Besides LC-MS/MS also LC-UV (Shearer 2002 Stratford 1999) and capillary electrophoresis (Clohs et al. 2002) are described. [Pg.512]

See other pages where Protein Modification Screening Tool is mentioned: [Pg.22]    [Pg.699]    [Pg.180]    [Pg.155]    [Pg.162]    [Pg.6]    [Pg.74]    [Pg.38]    [Pg.635]    [Pg.641]    [Pg.269]    [Pg.16]    [Pg.278]    [Pg.167]    [Pg.69]    [Pg.587]    [Pg.470]    [Pg.60]    [Pg.97]    [Pg.103]    [Pg.2894]    [Pg.47]    [Pg.197]    [Pg.699]    [Pg.249]    [Pg.114]    [Pg.1757]    [Pg.42]    [Pg.447]   
See also in sourсe #XX -- [ Pg.634 ]



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Protein Modification Screening

Proteins, modification

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