Protein hydrocortisone effects

Fatty acid synthetase is also subject to both adaptive changes in enzyme content as well as short-term metabolic control. The latter effects are ill-defined (Wakil et al., 1983) but diet, triiodothyronine, hydrocortisone and insulin effects have been noted on the amount of synthetase protein. Hydrocortisone and tri-iodothyronine have no effect alone but potentiate the insulin induction of synthetase (Wakil et al., 1983). The increases in synthetase activity on refeeding or insulin administration are due to an increase in transcription of mRNA which is elevated 70-fold (Morris et al., 1982). 

Theory Cortisol (or hydrocortisone) was introduced in the year 1951, for the treatment of rheumatoid arthritis. It has a significant effect on protein metabolism. It also exerts widespread effects on carbohydrates, lipid and protein synthesis (or anabolism). The cardinal side effects such as excessive potassium excretion and sodium retention, enhanced gastric acidity, oedema, psychosis and negative nitogen balance are some of the exaggerated manifestations of the normal metabolite functions of cortisol. 

Mechanism of Action Clioquinol is a broad-spectrum antibacterial agent but the mechanism of action is unknown. Hydrocortisone is a corticosteroid that diffuses across cell membranes, forms complexes with specific receptors and further binds to DNA and stimulates transcription of mRNA (messenger RNA) and subsequent protein synthesis of various enzymes thought to be ultimately responsible for the anti-inflammatory effects of corticosteroids applied topically to the skin Therapeutic Effect Alters membrane function and produces antibacterial activity Pharmacokinetics Clioquinol may be absorbed through the skin in sufficient amounts. 

Plasma proteins. Oestrogens cause an increase in proteins, particularly the globulins that bind hydrocortisone, thyroxine and iron. As a result, the total plasma concentration of the boimd substances is increased, though the concentration of free and active substance remains normal. This can be misleading in diagnostic tests, e.g. of thyroid function. This effect on plasma proteins passes off about 6 weeks after cessation of the oestrogen. 

Corlan hydrocortisone, corticoliberin corticotrophin-releasing factor, corticorelin corticotrophin-releasing factor. CORTICOSTEROIDS as a family are natural steroid hormones secreted by the adrenal cortex, or are synthetic substances that closely resemble them. There are two main types GLUCOCORTICOIDS (corticosterone. cortisone and hydrocortisone) are essential for utilization of carbohydrate, fat and protein in the body, and in the normal response to stress. Naturally occurring and synthetic glucocorticoids have a powerful antiinflammatory effect. 

Forster C, Burek M, Romero lA, Weksler B, Couraud P-O, and Drenckhahn D (2008) Differential effects of hydrocortisone and TNFa on tight junction proteins in an in vitro model of the human blood-brain barrier. J Physiol 586 1937-1949. 

Figure 2. Effect of hydrocortisone on the levels of liver XDH in the chick. Chicks were fed FRM starter diet (15% protein) for 15 days, then switched to the starter supplemented with hydrocortisone as shown. Livers from three chicks were pooled for each assay.

---