Protein expression changes

Levels of cytoskeletal protein expression change after injury and during regeneration 134... 

Prasad, S.C., P.J. Thraves, A. Dritschilo, and M.R. Kuettel. 1997. Protein expression changes associated with radiation-induced neoplastic progression of human prostate epithelial cells. Electrophoresis. 18 629-37. 

Figure 1 In the field of omics , the science for evaluating protein expression changes is termed as proteomics gene expression changes is termed as transcriptonomics/genomics , and metabolite changes is termed as metabonomics .

Anderson, K., Potter, A., Baban, D., and Davies, K.E. Protein expression changes in spinal muscular atrophy revealed with a novel antibody array technology. Brain 126, 2052-2064 (2003). 

Zabel C, Mao L, Woodman B, Rohe M, Wacker MA, Klare Y, Koppelstatter A, Nebrich G, Klein O, Grams S, Strand A, Luthi-Carter R, Haiti D, Klose J, Bates GP (2009) A large number of protein expression changes occur early in life and precede phenotype onset in a mouse model for huntington disease. Mol Cell Proteomics 8 720-734... 

Li, G. Laszio, A. (1985). Thermotolerance in mammalian cells A possible role for the heat shock proteins. In Changes in Eukaryotic Gene Expression in Response to Environmental Stress (Atkinson, B.G. Walden, D.B. eds.), pp. 349-371, Academic Press, Orlando. 

Proteome profiling allows quantitative and global examination of the changes in protein expression in different strains or cells under different conditions. Two-dimensional gel... 

Iron homeostasis in mammalian cells is regulated by balancing iron uptake with intracellular storage and utilization. As we will see, this is largely achieved at the level of protein synthesis (translation of mRNA into protein) rather than at the level of transcription (mRNA synthesis), as was the case in microorganisms. This is certainly not unrelated to the fact that not only do microbial cells have a much shorter division time than mammalian cells, but that one consequence of this is that the half-life of microbial mRNAs is very much shorter (typically minutes rather than the hours or often days that we find with mammals). This makes it much easier to control levels of protein expression by changing the rate of specific mRNA synthesis by the use of inducers and repressors. So how do mammalian cells... 

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