Protease virus-induced

MM Falk, PR Grigera, IE Bergmann, A Zibert, G Multhaup, E Beck. Foot and mouth disease virus protease 3C induces specific proteolytic cleavage of host cell histone H3. J Virol 64 748-756, 1990. 

There is a remarkable lack of effect of the virus-induced protease on cellular protein stability. This was measured by two-dimensional gel analysis of cellular proteins, labelled prior to infection. Samples were monitored up to the development of the cytopathic effect (Figure 8). The rapid cleavage of viral proteins is not observed at all with the cellular polypeptides, indicating a hi degree of specificity of the protease, or its sequestration from cellular struct-ures. 

Interference with assembly of viral coat proteins and viral RNA into new virus particles. Interferons may induce in the ribosomes of the host cells production of enzymes that inhibit translation of viral proteins. Avarol and avarine are thought to interfere with cytoskeletal assembly of virus particles. PROTEASE inhibitors can prevent the release of reverse transcriptase, and HIV-1 proteinase (e.g. saquinavir) are under development or in trial application. 

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