Antinociception action

Fleetwood-Walker S., Hope P., Mitchell R. (1988). Antinociceptive actions of descending dopaminergic tracts on cat and rat dorsal horn somatosensory neurones. J. Physiol, bond. 399, 335-48. 

Histamine also induces antinociceptive (i.e. pain-relieving) responses in animals after microinjection into several brain regions [73, 74]. H, and H2 mechanisms are significant and both neuronal and humoral mechanisms may be involved. Brain H2 receptors appear to mediate some forms of endogenous analgesic responses, especially those elicited by exposure to stressors [75]. Many of the modulatory actions of histamine discussed above appear to be activated as part of stress responses. For reasons that remain unclear, histamine releasers, such as thioperamide, show only mild, biphasic antinociceptive actions, even though histamine is a potent and effective analgesic substance. Outside the brain, both H and H3 receptors exist on certain types of sensory nerves and activation of these receptors promotes and inhibits, respectively, peripheral nerve transmission related to pain and/or inflammation [76,77]. 

Yeung JC, Rudy TA. (1980). Multiplicative interaction between narcotic agonisms expressed at spinal and supraspinal sites of antinociceptive action as... 

Bhargava HN, Cao YJ. (1997). Effects of noribogaine on the development of tolerance to antinociceptive action of morphine in mice. Brain Res. 771(2) 343-46. 

Cao YJ, Bhargava HN. (1997). Effects of ibogaine on the development of tolerance to antinociceptive action of mu-, delta-, and kappa-opioid receptor agonists in mice. Brain Res. 752(1-2) 250-4. Cappendijk SL, Dzoijic MR. (1993). Inhibitory effects of ibogaine on cocaine self-administration in rats. EurJ Pharmacol. 241(2-3) 261-65. 

Me5Te-Silva, C. et al.. Isolation of a C-glycoside fiavonoid with antinociceptive action from Aleurites moluccana leaves, Planta Med., 65, 293, 1999. 

Activities and sites of antinociceptive action of morphine-like analgesics, 6, 79... 

Borszcz, G. S. Differential contributions of medullary, thalamic, and amygdaloid serotonin to the antinociceptive action of morphine administered into the periaqueductal gray a model of morphine analgesia, Behav. Neurosci. 1999, 133, 612-631. 

Hamalainen, M. M. and Pertovaara, A. The antinociceptive action of an alpha2 adrenoceptor agonist in the spinal horn is due to a direct spinal action and not to activation of descending inhibition, Brain Res. Bull. 1995, 37, 581-587. 

Idanpaan, J. J., Kalso, E. A., Seppala, T.. Antinociceptive actions of dexmedetomidine and the K-opioid agonist U-50488H against noxious thermal, mechanical and inflammatory stimuli, J. Pharmacol. Exp. Ther. 1994, 271, 1306-1313. 

Sawynok, J., Reid, A. R., Esser, M. J. Peripheral antinociceptive action of amitriptyline in the rat formalin test involvement of adenosine, Pain 1999, 80, 45-55. 

However, due to the ubiquitous expression of K+ channels in virtually all excitable cells the general question arises how can they be exploited as targets for drug therapy of painful states To put it in other words, what is required to ascertain a specific antinociceptive action when modulating K+ channel functioning ... 

Second, the mechanisms by which altered K+ channels contribute to the development of chronic pain states and what needs must be met by the channels in order to constitute attractive drug targets with respect to the problem of ensuring a specific antinociceptive action will be discussed. Corresponding examples for this will be given. 

Asano, T., Dohi, S., lida, H. Antinociceptive action of epidural KATP channel openers via interaction with morphine and an a2-adrenergic agonist in rats, Anesthesia and Analgesia 2000, 90, 1146-1151. 

Al-Humayyd, M.S. Effect of diltiazem, nifedipine and verapamil on the antinociceptive action of acetylsalicylic acid in mice, Gen. Pharmac.1991, 22, 121-125. 

Chizh, B. A., Reifimuller, E., Schlutz, H., Scheede, M., Haase, G., Englberger, W. Supraspinal vs. Spinal sites of the antinociceptive action of the subtype-selective NMDA antagonist ifenprodil, Neuropharmacology 2001, 40, 212-220. 

Cheng JK, Chiou LC (2006) Mechanisms of the antinociceptive action of gabapentin. J Pharmacol Sci 100 471-86... 

Sawamura S, Kingery WS, Davies MF, Agashe GS, Clark JD, Kobilka BK, Hashimoto T, Maze M (2000) Antinociceptive action of nitrous oxide is mediated by stimulation of noradrenergic neurons in the brainstem and activation of a2is adrenoceptors. J Neurosci 20 9242-51 Scheibner J, Trendelenburg AU, Hein L, Starke K (2001a) a2-adrenoceptors modulating neuronal serotonin releases study in a2-adrenoceptor subtype-deficient mice. Br J Pharmacol 132 925-33... 

Linalool is a natural compound with anti-inflammatory and antinociceptive properties. The antinociceptive action of Iinalool has been reported in several models of inflammatory pain. However, its effects in neuropathic pain have not been investigated. Here, we used the spinal nerve ligation (SNL) model of... 

In contrast, the nonequilibrium 2antagonist naltrindole Shsothiocya-nate (5-NTII) [36] blocked the antinociceptive action of ICV [D-Ala2,... 

SELECTIVE DELTA OPIOID RECEPTOR AGONISTS AND THEIR ANTINOCICEPTIVE ACTIONS... 

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