Prostaglandins transporter

Young I can explain ATP. I did these experiments looking at intercellular Ca2+ waves and apyrase, and there is no effect. It turns out that the presence of either a prostaglandin transporter blocker, which is the same class as a Cl channel blocker, or a prostaglandin synthesis inhibitor, interrupts intracellular Ca2+ that is far away. It does not interrupt the intercellular Ca2+ through the gap junctions there are two different mechanisms. 

Young I think it is just agonist stimulation. In the intercellular wave propagation the sequential cells are producing prostaglandin, transporting Ca2+ from the inside to the outside and diffusing to the adjacent cell. This is the mechanism for the fan... 

Lu R, Kanai N, Bao Y, Schuster VL. Cloning, in vitro expression, and tissue distribution of a human prostaglandin transporter cDNA (hPGT). J Clin Invest 1996 98 1142-1149. 

Schuster VL. 1998. Molecular mechanisms of prostaglandin transport. Annu. Rev. Physiol. 60 221—42... 

The prostaglandin transporter PGT-2 was expressed in various tissues. It has 97.6% homology with OATP3A1. Thyroid hormones are general substrates for PGT-2 [26]. 

Nomura, T., R. Lu et al. 2004. The two-step model of prostaglandin signal termination In vitro reconstitution with the prostaglandin transporter and prostaglandin 15 dehydrogenase. Mol Pharmacol 65(41 973-978. 

Schuster, V. L. 2002. Prostaglandin transport. Frostailandins Other Livid Mediat 68-69 633-647. 

The first prostanoid carrier to be characterized was the rat prostaglandin transporter PGT, a member of the organic anion transporter polypeptide gene family (Schuster, 2002). Tracer prostanoids are transported in the rank order ... 

Bao, Y, Pucci, ML, Chan, BS, Lu, R, Ito, S and Schuster, VL (2002) Prostaglandin transporter PGT is expressed in ceh types that S5mthesize and release prostanoids. AmJ Physiol Renal Physiol, 282, F1103-F1110. 

Schuster, VL (2002) Prostaglandin transport. Prostaglandins Other Lipid Mediat, 69, 633-647. 

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