Prostaglandins dehydrogenase

Nomura, T., R. Lu et al. 2004. The two-step model of prostaglandin signal termination In vitro reconstitution with the prostaglandin transporter and prostaglandin 15 dehydrogenase. Mol Pharmacol 65(41 973-978. 

Coggins KG, Latour A, Nguyen MS et al (2002) Metabolism of PGE2 by prostaglandin dehydrogenase is essential for remodeling the ductus arteriosus. Nat Med 8 91-92... 

This enzyme [EC 1.1.1.50], also referred to as hydroxy-prostaglandin dehydrogenase, catalyzes the reaction of androsterone with NAD(P)+ to produce 5a-androstane-3,17-dione and NAD(P)H. Other 3a-hydroxysteroids can act as substrates as well as 9-, 11- and 15-hydroxy-prostaglandins. The stereochemistry is B-specific with respect to the pyridine coenzymes. 

Phosphatidic acid phosphatase Post proline cleaving enzyme Prostaglandin dehydrogenase Succinate dehydrogenase Sulfotransferase... 

Immunosuppression and Antiinflammatory Effects In addition to its ability to suppress myometrial and endometrial prostaglandin formation, progesterone suppresses T-lymphocyte proliferation, interleukin-8 synthesis, and increases prostaglandin dehydrogenase activity, all of which contribute to preventing maternal rejection of the implanting conceptus (an allograft). 

Cheng, L., Kelly, R.W., Thong, K.J., Hume, R. and Baird, D.T. (1993) The effects of mifepristone (RU486) on prostaglandin dehydrogenase in decidual and chorionic tissue in early pregnancy Human Reproduction, 8, 705-709. 

An enzymatic method of analysis which employs a specific nicotinamide-adenine dinucleotide-dependent prostaglandin dehydrogenase from swine lung permits analysis of prostaglandins with a lower limit of 10 mole [72]. 

Studies in the intact lung [173-179] have shown that prostaglandins Ej, Ej and F2c are almost completely inactivated on one passage through the pulmonary circulation but that PG s Ai and A2 are unaffected. Besides its presence in the lung, prostaglandin dehydrogenase activity has been located in the kidney [180-182] and the liver [183]. 

Figure 2. Tentative metabolic pathway of 8-iso-prostaglandin in the rabbit. (Reprinted with kind permission from Basu, FERS 1998c.) 15-PGDH, 15-prostaglandin dehydrogenase.

A. 17,20 lyase is required for androgen synthesis, cyclooxygenase for prostaglandin production, 11- 3-hydroxysteroid dehydrogenase-2 acts as a reductase-converting cortisol to its inactive 11-keto derivative cortisone, whereas 18-hydroxylase is required for aldosterone production. 

A similar mechanism has been found for 17(3-hydroxysteroid dehydrogenase (17(3-HSD), the enzyme that regulates the concentrations of estradiol and testosterone in human [5,16,17] (Figure lb). Genetics diseases associated with mutations in this enzyme lead to developmental abnormalities [18]. Enzymes that regulate the concentrations of retinoids [19] and prostaglandins [20] may also have a similar role [6]. 

Baker ME. Genealogy of regulation of human sex and adrenal function, prostaglandin action, snapdragon and petunia flower colors, antibiotics, and nitrogen fixation functional diversity from two ancestral dehydrogenases. Steroids 56 1991 354-360. 

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