Proprietary names index

The approach is to analyze a list of the basic new agents introduced to medical practice in the U.S. since 1941, using the DeHaen New Product Survey and Non-Proprietary Name Index as primary source materials (1). The DeHaen lists, which contain many kinds of new drug products, have been culled according to a set of exclusion rules we have devised to make them a more meaningful index of the rate of bona fide drug discovery. 

A good look at the index of this book indicates the items commonly encountered in examinations. The index is an exhaustive one and is divided into proprietary names, generic names, subject areas and conditions. A self-assessment exercise is to check that you have adequate knowledge of examples of the topics listed above and then attempt the tests. A review of the drugs in the index provides examples of medicines that certainly need attention. You should be familiar with the action, classification, side-effects, clinically significant drug interactions, contraindications and cautions of a number of classes of drugs, such as ... 

Many a brand name is not listed in the index Proprietary Name Generic Name. In these cases, it will be useful to consult the packaging information, which should list the generic (nonproprietary) name or INN. 

INDOMEE, INDQPTIC, METTNDOL, and MEZOLIN. Additional chemical and proprietary names are listed in the monograph for indomethacin in the Merck Index(ll). 

The generic name, the standard being the WHO International Non-proprietary Name, is the first choice of the EMBASE indexers and for combination preparations the brand name is preferred. However, EMBASE allows drugs to be indexed under numerous names, more so than MEDLINE, and even includes the name of the manufacturer if it is in the original article. EMBASE concentrates more on the pharmacological and toxicological aspects of the biomedical literature than MEDLINE. 

The usual names such as INN (International Non proprietary Names), INNv (proposed International Nonproprietary Names) and other customary names are given in the indexes. In addition, with the spectra of all pharmaceutical substances (with the exception of complex molecules and polymers) the chemical structural formulas and the relative molecular weights are indicated. Therefore the designation by scientific nomenclature has been dispensed with. 

The Rule-of-Five (Ro5) is one of the best known and widely accepted drug-likeness filters. The Ro5 was derived from an analysis of 2,245 drug candidates from World Drug Index (WDI) with assigned United States Adopted Name (USAN) or International Proprietary Name (INN) that are believed to have reached Phase II trials. It states that a compound violating any two of the following rules is likely to be poorly absorbed ... 

Dexamethasone (I) is 9a-fluoro-llS,17a,21-trihy-droxy-16a-methylpregna-l,4-dlene-3,20-dione. Other names for Che compound Include 9a-fluoro-16a-methylprednisolone and 16a-methyl-9a-fluoroprednisolone. The Merck Index lists three other chemical names for dexamethasone. Proprietary names for dexamethasone include Decadron, Dexacortisyl, Oradexon, Hexadrol and Deronll. A number of others are listed in the monograph for dexamethasone in the Merck Index. ... 

Some of the products listed are registered trademarks however for purposes of this Index, trademarks have not been differentiated from generic names. Absence of trademark indication does not exclude the possibility that the name may be a proprietary name or the subject of proprietary rights. 

The Association of British Pharmaceutical Industry (London), publishes a Directory of Members, while the British and Overseas Pharmacist s Year Book (London, British and Colonial Druggist Ltd.) provides an alphabetical list of manufacturers and gives information on schools of pharmacy in many countries and institutions. The Chemist and Druggist Diary and Yearbook (Morgan) lists pharmaceutical suppliers, has a trade names index and also provides information on societies and institutions. The Pharmaceutical Society publishes annually an Index of New Products which gives the names and addresses of manufacturers with some technical information, while similar data with a list of trade names is given in the London Medical Handbook (British and Colonial Druggist Ltd.). Manufacturers are also listed alphabetically in the Proprietary Articles Trade Association Yearbook, and in the Retail Chemist Trade Price List of Proprietary Articles (London, Drury Press) which contains a list of trade names. British Chemical Plant (British Chemical Plant Manufacturers Association) lists its members. 

Only those synonyms are listed here which are not to be found in the corresponding index in Meyer s Side Effects of Drugs Volume VIII. This list, in combination with the one in Meyler s SED VllI, necessarily presents only a small selection of the proprietary and alternative names under which drugs may be sold and used, followed in each case by the most usual generic, chemical, or official equivalent. The lists have been drawn up to cover those names most widely used internationally. 

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