Propionic 2-bromo-, ethyl ester

The reaction of potassium 3-amino-4-oxo-3,4-dihydroquinazoline-2-thiolate 62 with a-bromophenylacetic acid 63 resulted in the formation of (3-amino-4-oxo-3,4-dihydroquinazolin-2-ylsulfanyl)-phenyl-acetic acid methyl ester 64 which on alkali treatment and subsequent acidification resulted in the synthesis of 2-phenyl- 1-thia-4,4a,9-triaza-anthracene-3,10-dione 65 <1999JCR(S)86>. Similarly, the reaction of potassium 3-amino-5,6-dimethyl-4-oxo-3,4,4a,7a-tetrahydrothieno[2,3- pyrimidine-2-thiolate 66 with a-bromo-ester 67 resulted in the formation of 2-(3-amino-5,6-dimethyl-4-oxo-3,4,4a,7a-tetrahydrothieno[2,3- / pyrimidin-2-ylsulfanyl)-propionic acid ethyl ester 68. Subsequent treatment with alkali followed by acidification resulted in the formation of 2,3,7-trimethyl-3a,9a-dihydro-l,8-dithia-4a,5,9-triazacyclopenta[ ]naphthalene-4,6-dione 69 <2000JHC1161>... 

Sodium 2-Bromo-2-methyl-propionic acid ethyl ester... 

CsHsBrOj ( )-2-bromo-propionic acid ethyl ester 41978-69-2 ... 

Propionic acid, 2-iodo-3-nitro-, ethyl ester [Propanoic acid, 2-iodo-3-mtro-, ethyl ester], 65 2//-Pyran, 3,4-dihydro-, 51 2//-PYR AN-2-ONE, 49 2H Pyran 2-one, 5 bromo 5,6-dihydro, 50 27/-PYRAN-2-ONE, 5,6 DIHYDRO-, 49 PYRIDINE, 2,3,4,5 TETRAHYDRO, 118 Pyridines, -substituted, 34 a Pyrone-6-carboxyhc acid [2H Pyran-6-Larboxyhc acid 2-oxo ], 51 Pyrroles, 34... 

In a more detailed study, the same esterase P. fluorescens) was again subjected to mutagenesis using the same mutator strain, but also by saturation mutagenesis at selected positions 133a). In addition to 3-phenylbutyric acid ethyl ester (27), 3-bromo-2-methyl-propionic acid methyl ester rac-31) was chosen for the hydrolytic kinetic resolution, with the WT PFE showing an E factor of 12 in favor of the (5)-32. 

This ester has been prepared by the action of ethyl jS-bromo-propionate on methylamine hydrochloride in the presence of silver oxide,1 by the addition of methylamine to ethyl acrylate,2 and by heating ethyl /3-chloropropionate, methylamine, and benzene in an autoclave.3... 

Further improvements resulted from the use of a probe for sonication.325 Jhe higher reactivity seems not to be due to an increased surface area, but rather to morphological and composition changes, as evidenced by electron microscopy and sputtered neutral mass spectrometry.i< When applied to ethyl bromo propionate and trifluoroacetaldehyde, the resulting p-hydroxy esters are obtained in good yields with predominance of the threo isomer.272... 

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