Properties of 0-glucuronidase

The level of jS-D-glucuronidase activity in human-skin fibroblasts from patients with Maroteaux-Lamy syndrome has been shown to be normal. The activities and properties of )3-D-glucuronidase in embryonic human-lung (diploid Wl-38) fibroblasts have been reported. ... 

M. C. Gehrmann, M. Opper, H. H. Sedlacek, K. Bosslet, J. Czech, Biochemical Properties of Recombinant Human /3-Glucuronidase Synthetized in Baby Hamster Kidney Cells , Biochem. J. 1994, 301, 821 - 828. 

Exposure of animals to ozone lowers their resistance to bacterial infection of the limgs ( ). Ozone exposure also causes changes in the properties of material that can be lavaged from the lungs there is inactivation of the enzymes acid phosphatase, 3-glucuronidase and lysozyme, and there is a tendency for these enzymes to have been released from the alveolar macrophage cells ( ). vivo inactivation of lung lysozyme has... 

A large number of substances have been shown to have the property of inhibiting /3-D-glucuronidase. The most potent of all, according to Lewy,68 is D-glucaro-1,4-lactone (XXXVI), whose structure is shown below for comparison with that of a /3-D-glucosiduronic acid (XXXVII). This in-... 

The levels of /3-D-glucuronidase activity in skin fibroblasts from cases of cystic fibrosis and controls have been compared. The purification (470 fold, 46 % yield, 6 stages) of the saline extractable jS-D-glucuronidase from human leucocytes and some of its catalytic and molecular properties have been reported. Comparisons of these properties were made with those of other human and non-human jS-o-glucuronidases. The subcellular distribution of glycoside hydrolases including jS-o-glucuronidase in human polymorphonuclear leucocytes has been determined. ... 

Three isoenzymes of carboxylesterase were purified from rat liver micro-somes and were named RL1, RL2, and RH1. These differ from each other in their response to hormone treatment, inducibility, substrate specificity, and immunological properties [75], It was shown that RL1, RL2, and RH1 resemble hydrolases p/ 6.2/6.4, pI 6.0, and pI 5.6, respectively. Enzyme RL2 was found to be identical to egasyn, a protein with esterase activity found in the endoplasmic reticulum [76], The role of egasyn is to stabilize glucuronidase (EC 3.2.1.31) by noncovalent binding to the microsomal membrane. 

E. coli 0157 H7 has the same phenotypic properties as the majority of E. coli species with the exception of sorbitol fermentation and (3-D-glucuronidase activity. Unlike 95% of E. coli strains, 0157 H7 strains do not ferment sorbitol in 2... 

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