2-propanone manufacture

CH3C(0)CH2Br. Colourless liquid which rapidly becomes violet in colour it is a powerful lachrymator b.p. 1367725 mm. Manufactured by treating aqueous propanone with bromine at 30-40 C it is usual to add sodium chlorate(V) to convert the hydro-bromic acid formed by the reaction back to bromine. It is not very stable and decomposes on standing. 

C4H8O, CH3COCH2CH3. Colourless liquid with a pleasant odour, b.p. 80°C. It occurs with propanone in the products of the destructive distillation of wood. Manufactured by the liquid or vapour phase dehydrogenation of 2-butanol over a catalyst. Used as a solvent, particularly for vinyl and acrylic resins, and for nitrocellulose and cellulose acetate, also for the dewaxing of lubricating oils. U.S. production 1978 300 000 tonnes. 

CH2CI-CO-CH3. Colourless lachrymatory liquid b.p. 119°C. Manufactured by treating propanone with bleaching powder or chlorine. It is used as a tear gas and is usually mixed with the more potent bromoacetone. chloro acids Complex chloroanions are formed by most elements of the periodic table by solution of oxides or chlorides in concentrated hydrochloric acid. Potassium salts are precipitated from solution when potassium chloride is added to a solution of the chloro acid, the free acids are generally unstable. 

Colourless liquid b.p. 69 5 C. Manufactured from propanone by conversion to pinacone and passing its vapour over heated KHSO4. Slowly changes to a rubber-like substance the change is hastened by metallic sodium or peroxides. Used in the manufacture of artificial rubber. 

CHi=CMeCOOH. Colourless prisms m.p. 15-16 C, b.p. 160-5 C. Manufactured by treating propanone cyanohydrin with dilute sulphuric acid. Polymerizes when distilled or when heated with hydrochloric acid under pressure, see acrylic acid polymers. Used in the preparation of synthetic acrylate resins the methyl and ethyl esters form important glass-like polymers. 

CH3CH2OHCH3. B.p. 82 C. Manufactured by hydrolysis of propene. Used in the production of acetone (propanone) by oxidation, for the preparation of esters (e.g. the ethanoate used as a solvent), amines (diisopropylamines, etc.), glycerol, hydrogen peroxide. The alcohol is used as an important solvent for many resins, aerosols, anti-freezes. U.S. production 1978 775 000 tonnes. 

Propanone is the main component of most nail polish removers. It is used as a solvent, and in the manufacture of plastics. 

With regard to other key chemicals used in the illicit manufacture of amphetamine-type stimulants, such as 3,4-methylenedioxyphenyl-2-propanone (3,4-MDP-2-P), l-phenyl-2-propanone (P-2-P) and safrole, it has been noted that no country reported any exports of 3,4-MDP-2-P for 2003. Several European countries, including Belgium, France and Germany,... 

Note Approximately 250 litres of 3,4-methlenedioxyphenyl-2-propanone (3,4-MDP-2-P) are required to manufacture 100 kg of 3-4-methylenedioxyamphetamine (MDA) hydrochloride and 125 litres of... 

Methylenedioxyphenyl- 2-propanone Used in the manufacture of piperonal and other perfume components. 

Phenyl-2-propanone Used in the chemical and pharmaceutical industries for the manufacture of amphetamine, methamphetamine and some derivatives used for the synthesis of propylhexedrine. 

P-2-P or l-phenyl-2-propanone, also known as BMK, is typically used for the manufacture of amphetamine, but can be also used for methamphetamine phenyl acetic acid is a precursor for the production of P-2-P and thus a pre-precursor for the manufacture of amphetamine. 

There are two major processes for the production of acetone (2-propanone). The feedstock for these is either Ao-propyl alcohol [(CH3)2CHOH] or cumene [ Ao-propyl benzene, C6H5CH(CH3)2]. In the last few years there has been a steady trend away from Ao-propyl alcohol and toward cumene, but Ao-propyl alcohol should continue as a precursor since manufacture of acetone from only cumene would require a balancing of the market with the coproduct phenol from this process. 

Phenylacetic acid is an immediate precursor of l-phenyl-2-propanone (P-2-P), a substance in Table I of the 1988 Convention that is used in the manufacture of amphetamine and methamphetamine. Concerned by the increase in seizures of phenylacetic acid and illicitly manufactured P-2-P, the Board instructed its advisory expert group2 to review the situation. The review, conducted in October 2006, found that the illicit manufacture of both amphetamine and methamphetamine appeared to be on the rise, posing a threat to public health and lying at the root of other social problems. The Board concluded that the controls required for the substances in Table II of the Convention were insufficient to prevent diversions of phenylacetic acid. On that basis and having assessed the relevant comments and supplementary information provided by Governments pursuant to article 12 of the Convention, the Board submitted a communication to the Secretary-General in January 2007 to formally initiate the procedures for the transfer of phenylacetic acid from Table II to Table I of the Convention. 

Annual legitimate requirements for ephedrine, pseudoephedrine, 3,4-methylenedioxyphenyl-2-propanone and 1-phenyl-2-propanone, substances frequently used in the manufacture of amphetamine-type stimulants... 

IUicit manufacture of methylenedioxymethamphetamine and related drugs scheduled substances and the approximate quantities of them required for the manufacture of 100 litres of 3,4-methylenedioxyphenyl-2-propanone... 

The only ketone which we shall consider is acetone, CH3—CO— CH3, or propanone, also called di-methyl ketone. Acetone is a liquid that boils at 56.5°. It has a peculiar odor, and is soluble in all proportions in water. It is a valuable solvent for many organic substances, and is used in the manufacture of explosives and in important synthetic reactions. It is the third important constituent of crude wood alcohol or pyroligneous acid, being formed as a product of the dry distillation of wood. Table XIII gives the names, formulas and boiling" points of a few of the more common and important ketones. 

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