Promyelocytic leukemia zinc-finger protein

Weidemann W, Stelzl U, Lisewski U et al. (2006) The collapsin response mediator protein 1 (CRMP-1) and the promyelocytic leukemia zinc finger protein (PLZF) bind to UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNB), the key enzyme of sialic acid biosynthesis. FEBS Lett 580, 6649-6654. 

Collapsin response mediator protein 1, promyelocytic leukemia zinc-finger protein, and a-actinin 1 new molecular partners of GNE/MNK... 

In vitro studies have shown that GNE/MNK is able to interact with factors such as the coUapsin response mediator protein 1 and the promyelocytic leukemia zinc-finger protein [35], but none of these molecular partners has been proven so far to be involved in the pathogenic cascade of h-IBM muscle. More recently, GNB/MNK has been demonstrated to physically interact also with a-actinin 1, and these two proteins partially colocalize in the sarcomere of mature muscle fibers. However, in vitro, no gross difference has been observed between the interaction of a-actinin 1 with wild-type GNB/MNK and mutated GNB/MNK [36]. Although this line of evidence provides novel interesting clues on additional roles of GNB/MNK outside of the sialic acid biosynthetic pathway, it remains to be determined how even a minor impairment of the interaction between a-ac-tinin 1 and GNB/MNK, as hypothesized in h-IBM, may impact the viability of muscle fibers. 

Dong S, Zhu J, Reid A, Strutt P, Guidez F, Zhong H-J, Wang Z-Y, Licht J, Waxman S, Chomienne C et al (1996) Amino-terminal protein-protein interaction motif (POZ-domain) is responsible for activities of the promyelocytic leukemia zinc finger-retinoic acid receptor-a fusion protein. Proc Natl Acad Sci USA 93 3624-3629... 

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