Promethazine Suppository

For nausea and vomiting associated with pediatric gastroenteritis, there is greater emphasis on rehydration measures than on pharmacologic intervention. Only two prospective studies have been published on the safety or efficacy of antiemetics in pediatric gastroenteritis since 1966. A recent survey of physicians revealed that promethazine suppositories were the most commonly prescribed antiemetic for pediatric gastroenteritis, despite the lack of prospective trials for this agent. ... [Pg.674]

Chlorpromazine (Thorazine) Chlorpromazine suppository Prochlorperazine (Compazine) Prochlorperazine suppository Promethazine (Phenergan) Thiethylperazine (Torecan)... [Pg.299]

Other antiemetics Promethazine (Phenergan) 25 mg PO/IV/rectal suppository Q4H... [Pg.145]

Show how you would prepare 12 promethazine hydrochloride suppositories containing 20 mg of the drug in each suppository. Assume that you are required to use cocoa butter and that the displacement value of promethazine hydrochloride is 2.5. [Pg.196]

S. Stavchansky, P. Wu, and J. E. Wallace, Gas-liquid chromatographic determination of promethazine in coca butter-white wax suppositories, Drug Dev. Ind. Pharm., 9 989 (1983). [Pg.257]

Strenkoski-Nix LC, Ermer J, DeCleene S, et al. (2000) Pharmacokinetics of promethazine hydrochloride after administration of rectal suppositories and oral syrup to healthy subjects. Am J Health-Syst Pharm 57 1499-1505. [Pg.223]

Each rectal suppository contains 12.5, 25, or 50 mg promethazine hydrochloride with ascorbyl palmitate, silicon dioxide, white wax, and cocoa butter. Promethazine hydrochloride is a racemic compound the empirical formula is C17H2oN2S HC1, and its molecular weight is... [Pg.231]

Kountourellis, J.E. Raptouli, A. Georgarakis, M. Simultaneous determination of aminophylline and promethazine in suppositories by high-performance liquid chromatography. Pharmazie, 1986, 41, 600-601... [Pg.1177]

An example of a simple oxidatiim reaction is the craiver-sion of Fe " into Fe. Examples of active substances that are prone to oxidation are acetylcystein, adrenaline, apomorphine, clioquinol, dithranol, dobutamine, ergotamine, hydroquinone, isoniazid, mesalazine, naloxone, neomycin, oxycodone, paracetamol, peptides, salbutamol, phenothiazine derivatives (promazine, promethazine, chlorpromazine), phenylephrine, physostigmine, tetracycline, tretinoin, the vitamins A and D, and the excipients flavouring agents, fragrances and unsaturated fats (vegetable oils, suppository bases). [Pg.438]

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