Promethazine hydrochloride suppositories

Show how you would prepare 12 promethazine hydrochloride suppositories containing 20 mg of the drug in each suppository. Assume that you are required to use cocoa butter and that the displacement value of promethazine hydrochloride is 2.5. [Pg.196]

Strenkoski-Nix LC, Ermer J, DeCleene S, et al. (2000) Pharmacokinetics of promethazine hydrochloride after administration of rectal suppositories and oral syrup to healthy subjects. Am J Health-Syst Pharm 57 1499-1505. [Pg.223]

Each rectal suppository contains 12.5, 25, or 50 mg promethazine hydrochloride with ascorbyl palmitate, silicon dioxide, white wax, and cocoa butter. Promethazine hydrochloride is a racemic compound the empirical formula is C17H2oN2S HC1, and its molecular weight is... [Pg.231]

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