Chlorpromazine suppositories

Chlorpromazine (Thorazine) Chlorpromazine suppository Prochlorperazine (Compazine) Prochlorperazine suppository Promethazine (Phenergan) Thiethylperazine (Torecan)... 

In suspension suppositories, the active substance is processed as small particles that are prone to form agglomerates. The effective dispersion of the agglomerates (see Sect. 29.3) is a prerequisite for a sufficient content uniformity. Lactose may be used in pharmacy preparations to disperse the agglomerates and to maintain separation of the primary particles. This is most important with low dosed active substances, which do not easily lead to a good content uniformity. If 50 mg or less of active substance(s) is used per suppository, as a standard 100 mg lactose may be added to each suppository, as illustrated by chlorpromazine suppositories in Table 11.4. The added lactose should not be considered as a filler only as it is in tablets or capsules, but its main function in suppositories is the dispersing of the active substance. 

Non-aqueous titration methods have been described for the rapid determination of chlorpromazine and its hydrochloride salt by titration with perchloric acid [54]. The titration is performed after the proscribed extraction from suppository, tablet, and ampoule dosage forms is completed. 

Chlorpromazine is administered orally, intravenously, intramuscularly, and via suppository. Pharmacists, physicians, and nurses dispensing or administering chlorpromazine could be exposed through dermal or inhalation contact. 

Each suppository contains chlorpromazine (25 or 100 mg), glycerin, glyceryl monopalmitate, glyceryl monostearate,... 

An example of a simple oxidatiim reaction is the craiver-sion of Fe " into Fe. Examples of active substances that are prone to oxidation are acetylcystein, adrenaline, apomorphine, clioquinol, dithranol, dobutamine, ergotamine, hydroquinone, isoniazid, mesalazine, naloxone, neomycin, oxycodone, paracetamol, peptides, salbutamol, phenothiazine derivatives (promazine, promethazine, chlorpromazine), phenylephrine, physostigmine, tetracycline, tretinoin, the vitamins A and D, and the excipients flavouring agents, fragrances and unsaturated fats (vegetable oils, suppository bases). 

The peroxide value is a measure of the number of peroxide bridges in the fat. Fats or oils with a low peroxide number (<0.5) are used for the processing of easily oxidisable substances. Examples are ergotamine tartrate and chlorpromazine hydrochloride in fatty suppositories. 

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