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Proline in addition

The smaller inactive components of AFGP (6-8) contain proline in addition to alanine and threonine (Tables II and IV). Chan (1971)... [Pg.207]

Three pyrrole nuclei exist in prodigiosin, and it was shown that one of these units is derived from proline. In addition, a C2 unit originated from... [Pg.142]

Ando, T., Abukumagawa, E., Nagai, Y., Yamasaki, M. (2) On the N-terminal residues and sequence of clupeine from Clupea pallasii The occurrence of proline in addition to alanine as the N-terminus. J. Biochem. (Tokyo) 44, 191—194 (1957). [Pg.96]

The most famous secondary amine employed in organocatalysis is proline. In addition to the examples reported in the introduction regarding the use of proline under aqueous conditions, it is worth further describing other apphcations of proline under the same conditions. No enantioselectivily was observed in prohne-catalyzed aldol reactions in phosphate buffer [38] and aqueous micelles [39]. When proline was used with camphorsulfonic acid as co-catalyst good yields and stere-oselechvities were obtained using a 4 1 (v/v) ketone water ratio [40]. [Pg.682]

Biochemical Functions. Ascorbic acid has various biochemical functions, involving, for example, coUagen synthesis, immune function, dmg metabohsm, folate metaboHsm, cholesterol cataboHsm, iron metaboHsm, and carnitine biosynthesis. Clear-cut evidence for its biochemical role is available only with respect to coUagen biosynthesis (hydroxylation of prolin and lysine). In addition, ascorbic acid can act as a reducing agent and as an effective antioxidant. Ascorbic acid also interferes with nitrosamine formation by reacting direcdy with nitrites, and consequently may potentially reduce cancer risk. [Pg.21]

In addition to effects on biochemical reactions, the inhibitors may influence the permeability of the various cellular membranes and through physical and chemical effects may alter the structure of other subcellular structures such as proteins, nucleic acid, and spindle fibers. Unfortunately, few definite examples can be listed. The action of colchicine and podophyllin in interfering with cell division is well known. The effect of various lactones (coumarin, parasorbic acid, and protoanemonin) on mitotic activity was discussed above. Disturbances to cytoplasmic and vacuolar structure, and the morphology of mitochondria imposed by protoanemonin, were also mentioned. Interference with protein configuration and loss of biological activity was attributed to incorporation of azetidine-2-carboxylic acid into mung bean protein in place of proline. [Pg.139]

These cytosolic proteins contain five EF-hand domains and are able to translocate to the plasma membrane upon calcium binding [5]. In addition to the EF-hand domains, these proteins also have a hydrophobic glycine/proline-rich domain, important for their translocation to the membrane. To date five members of this... [Pg.293]

In addition to phosphotriesterase from P. diminuta (PTE) discussed above, two other types of enzymes were found to exhibit phosphotriesterase activity. Interestingly, both are peptidases - the enzymes which in nature hydrolyse a peptide bond. The first one - organophosphorus acid anhydrolase (OPAA) from Alteromonas sp. JD6.5 - is a proline dipeptidase its original activity is to cleave a dipepfide bond with a prolyl residue at the carboxy terminus. The second one - aminopeptidase P (AMPP) from Escherichia coli - is a proline-specific peptidase that catalyses hydrolysis of N-terminal peptide bonds containing a proline residue. ° ... [Pg.195]

Reaction progress kinetic analysis offers a reliable alternative method to assess the stability of the active catalyst concentration, again based on our concept of excess [e]. In contrast to our different excess experiments described above, now we carry out a set of experiments at the same value of excess [ej. We consider again the proline-mediated aldol reaction shown in Scheme 50.1. Under reaction conditions, the proline catalyst can undergo side reactions with aldehydes to form inactive cyclic species called oxazolidinones, effectively decreasing the active catalyst concentration. It has recently been shown that addition of small amounts of water to the reaction mixture can eliminate this catalyst deactivation. Reaction progress kinetic analysis of experiments carried out at the same excess [e] can be used to confirm the deactivation of proline in the absence of added water as well to demonstrate that the proline concentration remains constant when water is present. [Pg.452]

A DFT study found a corresponding TS to be the lowest energy.167 This study also points to the importance of the solvent, DMSO, in stabilizing the charge buildup that occurs. A further computational study analyzed the stereoselectivity of the proline-catalyzed aldol addition reactions of cyclohexanone with acetaldehyde, isobu-tyraldehyde, and benzaldehyde on the basis of a similar TS.168 Another study, which explored the role of proline in intramolecular aldol reactions, is discussed in the next section.169... [Pg.132]


See other pages where Proline in addition is mentioned: [Pg.29]    [Pg.1171]    [Pg.142]    [Pg.23]    [Pg.273]    [Pg.44]    [Pg.230]    [Pg.29]    [Pg.1171]    [Pg.142]    [Pg.23]    [Pg.273]    [Pg.44]    [Pg.230]    [Pg.61]    [Pg.190]    [Pg.95]    [Pg.110]    [Pg.76]    [Pg.275]    [Pg.662]    [Pg.74]    [Pg.1258]    [Pg.197]    [Pg.148]    [Pg.124]    [Pg.119]    [Pg.2]    [Pg.94]    [Pg.145]    [Pg.227]    [Pg.220]    [Pg.101]    [Pg.271]    [Pg.115]    [Pg.36]    [Pg.117]    [Pg.248]    [Pg.264]    [Pg.88]    [Pg.106]    [Pg.219]    [Pg.333]    [Pg.187]    [Pg.81]    [Pg.166]    [Pg.7]    [Pg.133]   
See also in sourсe #XX -- [ Pg.27 ]




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